Table 2 List of hub-DEGs, and topmost DEmiRs, TFs and lncRNAs in the constructed multilayer regulatory network

DEGs

TP53

112

lncRNAs

HOTAIR

32

STAT3

73

MEG3

24

JUN

46

H19

21

FOS

43

MALAT1

20

DNMT1

38

UCA1

17

NOTCH1

37

CDKN2B-AS1

14

TGFB1

36

GAS5

10

E2F3

34

NEAT1

10

CREB1

34

PVT1

10

XIAP

34

HULC

9

SUMO1

33

VIM

32

TFs

EZH2

74

ETS1

29

MYC

56

ABCB1

27

NF-κB

39

COX6B1

26

DEmiRs

hsa-mir-16-5p

134

TERT

25

hsa-mir-92a-3p

108

CEBPB

25

hsa-let-7b-5p

105

CRK

24

hsa-mir-17-5p

102

TXNIP

24

hsa-mir-124-3p

97

CCNE1

22

hsa-mir-93-5p

95

FOXK1

22

SNRPD1

21

BAX

21

TAOK1

21

CRCP

21

BAX

21

TBL1XR1

20

HSP90AB1

20

Klf4

19

HNRNPA2B1

19