Table 1 Main clinical studies reporting renal histology in Inflammatory Bowel Disease

Ambruzs et al. [12]

45 CD

38 UC

24% IgA Nephropathy;

19%Interstitial Nephritis;

12% Nephrosclerosis;

8% Acute Tubular Injury;

7% Proliferative GN;

4% Minimal change disease;

• Prevalence of IgAN significantly higher in patients with IBD than in healthy population

• Association with HLA-DR1described in both IBD and IgAN

• All patients with interstitial nephritis were previously exposed to aminosalicylates

Jang et al. [13]

7 CD

5 IgA Nephropathy;

1 Henoch-Schönlein purpura;

1 No alterations;

Archimandritis et al. [14]

1 CD

Interstitial nephritis with granulomas

• Full recovery after proctocolectomy

Izzedine et al. [15]

4 CD

4 Interstitial Nephritis

• All diagnosed before administration of mesalazina

• Progression to end-stage renal failure in 3 patients

• Granulomas were identified in 2 patients

Hubert et al. [16]

1 CD

1 UC

IgA Nephropathy

• Restoration of renal findingsafter treatment for IBD

Ridder et al. [17]

1 UC

Membranous Nephropathy

• Presentation with intestinal manifestation

• Improvement after therapy

Pohjonen et al. [18]

14 CD

14 UC

7 UND

7 IgA Nephropathy;

2 Membranous Nephropathy;

2 IgM GN;

4 acute interstitial nephritis;

4 chronic interstitial nephritis;

• All patients with interstitial nephropathy had an history of mesalazina administration

Ota et al. [19]

1 CD

acute tubulointerstitial nephritis

• After the discontinuation of IFX, renal abnormalities resolved