All patients N = 300 | Patients meeting the BR criteria N = 78 (26%) | Patients not meeting BR criteria N = 222 (74%) | P-value | |
---|---|---|---|---|
Number of patients per hospital | CWH: 102/300 (34.0%) | CWH: 31/102 (30.4%) | CWH: 71/102 (69.6%) | |
VMC: 100/300 (33.3%) | VMC: 23/100 (23.0%) | VMC: 77/100 (77.0%) | ||
RUMC: 98/300 (32.7%) | RUMC: 24/98 (24.5%) | RUMC:74/98 (75.5%) | ||
Demographics patients | ||||
Gender, male (%) | 173 (57.5%) | 44 (56.4%) | 129 (58.1%) | 0.794 |
Age in years, median (range) | 67.5 (19–96) | 70 (25–88) | 67 (19–96) | 0.265 |
Number of outpatient visits, mean | 3.8 ± 1.66 (n = 259) | 3.0 ± 1.28 (n = 76) | 4.1 ± 1.69 (n = 183) | < 0.001 |
Aetiology | ||||
ADPKD* | 33/300 (11.0%) | 7/78 (9.0%) | 26/222 (11.7%) | 0.506 |
Glomerular diseases1 | 82/300 (27.3%) | 18/78 (23.1%) | 64/222 (28.8%) | 0.327 |
Systemic diseases2 | 20/300 (6.7%) | 0/78 (0.0%) | 20/222 (9.0%) | 0.006 |
Tubulointerstitial nephritis | 11/300 (3.7%) | 2/78 (2.6%) | 9/222 (4.1%) | 0.547 |
Drug-induced CKD | 7/300 (2.3%) | 2/78 (2.6%) | 5/222 (2.3%) | 0.875 |
Vascular CKD | 61/300 (20.3%) | 19/78 (24.4%) | 42/222 (18.9%) | 0.304 |
Diabetic nephropathy | 26/300 (8.7%) | 8/78 (10.3%) | 18/222 (8.1%) | 0.562 |
Other cause3 | 38/300 (12.7%) | 11/78 (14.1%) | 27/222 (12.2%) | 0.658 |
Unknown cause | 20/300 (6.7%) | 11/78 (14.1%) | 9/222 (4.1%) | 0.002 |
Measurements | ||||
eGFR (ml/min/1.732), mean | 42 ± 21.07 | 46 ± 19.95 | 40 ± 21.3 | 0.044 |
Stage proteinuria, (%) | 0.007 | |||
A1 | 47/296 (15.9%) | 15/78 (19.2%) | 32/218 (14.7%) | |
A2 | 121/296 (40.9%) | 41/78 (52.6%) | 80/218 (36.7%) | |
A3 | 128/296 (43.2%) | 22/78 (28.2%) | 106/218 (48.6%) | |
Haemoglobin (g/dl), mean | 13.21 ± 1.79 (n = 253) | 13.54 ± 1.82 (n = 72) | 13.05 ± 1.77 (n = 181) | 0.054 |
Potassium (mmol/L), mean | 4.5 ± 0.49 (n = 265) | 4.4 ± 0.39 (N = 78) | 4.5 ± 0,53 (n = 187) | 0.865 |
Phosphate (mmol/L), mean | 1.05 ± 0.28 (n = 224) | 1.01 ± 0.29 (n = 63) | 1.06 ± 0.27 (n = 161) | 0.196 |
Systolic blood pressure (mm Hg), mean | 131 ± 16.6 (n = 283) | 131 ± 16.49 (n = 76) | 131 ± 16.7 (n = 207) | 0.967 |
Diastolic blood pressure (mm Hg), mean | 73 ± 9.96 (n = 283) | 74 ± 8.37 (n = 76) | 73 ± 10.48 (n = 207) | 0.424 |
Comorbidity | ||||
Angina pectoris | 33/271 (12.2%) | 10/77 (13.0%) | 23/194 (11.9%) | 0.797 |
Myocardial infarction | 42/272 (15.4%) | 16/78 (19.8%) | 26/194 (13.4%) | 0.142 |
Heart failure | 30 /270 (11.1%) | 15/78 (19.2%) | 15/192 (7.8%) | 0.007 |
Hypertension (K86.87) | 180/274 (65.7%) | 53/78 (67.9%) | 127/196 (64.8%) | 0.620 |
TIA or CVA | 38/272 (14.0%) | 17/78 (21.8%) | 21/194 (10.8%) | 0.018 |
Hemiplegia | 0/271 (0%) | 0/78 (0%) | 0/193 (0%) | NA |
Peripheral vascular disease | 41/270 (15.2%) | 9/77 (11.5%) | 32/193 (16.6%) | 0.312 |
Diabetes mellitus | 74/270 (27.4%) | 21/77 (27.3%) | 53/193 (27.5%) | 0.608 |
Uncomplicated | 35/270 (13.0%) | 8/77 (10.4%) | 27/193 (14.0%) | |
Complicated | 39/270 (14.4%) | 13/77 (16.9%) | 26/193 (13.5%) | |
COPD | 20/272 (7.4%) | 6/78 (7.7%) | 14/194 (7.2%) | 0.892 |
Dementia | 0/272 (0%) | 0/78 (0%) | 0/194 (0%) | NA |
Liver disease | 6/270(2.3%) | 0/78 (0%) | 6/192 (3.1%) | 0.288 |
Mild | 5/270 (1.9%) | 0/78 (0%) | 5/192 (2.6%) | |
Moderate / severe | 1/270 (0.4%) | 0/78 (0%) | 1/192 (0.5%) | |
HIV or AIDS | 1/271 (0.3%) | 0/77 (0%) | 1/194 (0.5%) | 0.528 |
Cancer | 53/269 (19.7%) | 13/77 (16.9%) | 40/192 (20.8%) | 0.042 |
Solid tumour | 51/269 (19%) | 11/77 (14.3%) | 40/192 (20.8%) | |
Metastatic | 2/269 (0.7%) | 2/77 (2.6%) | 0/192 (0%) | |
Haematological malignancy | 4/269 (1.5%) | 0/78 (0%) | 4/191 (2.1%) | 0.198 |
Connective tissue disease | 21/273 (7.7%) | 4/77 (5.2%) | 17/196 (8.7%) | 0.332 |
Peptic ulcer | 6/271 (2.2%) | 2/77 (2.6%) | 4/194 (2.1%) | 0.787 |
Charlson Comorbidity Index, median (range) | 5.3 (0–15) (n = 219) | 5.3 (0–15) (n = 69) | 5.3 (0–12) (n = 150) | 0.938 |
Medication | ||||
Angiotensin receptor blockers | 186/272 (68.4%) | 50/78 (64.1%) | 136/194 (70.1%) | 0.336 |
Diuretics | 92/269 (34.2%) | 25/76 (32.9%) | 67/193 (34.7%) | 0.777 |
Beta blockers | 130/272 (47.8%) | 38/78 (48.7%) | 92/194 (47.4%) | 0.847 |
Calcium channel blockers | 105/272 (38.6%) | 25/78 (32.1%) | 80/194 (41.2%) | 0.159 |
Vitamin D / alfacalcidol | 151/271 (55.7%) | 39/78 (50.0%) | 112/193 (58.0%) | 0.228 |
Erythropoeitin | 19/272 (6.3%) | 4/78 (5.1%) | 15/194 (7.7%) | 0.446 |
Phosphate binders | 10/272 (3.7%) | 0/78 (0%) | 10/194 (5.2%) | 0.041 |
Immunosuppressive drugs | 67/300 (22.3%) | 0/78 (0%) | 67/222 (30.2%) | < 0.001 |