Table 2 Clinical Characteristics and Donor-specific Data according to HCMV status in Urinary Sediment of RTX Patients. ATG antithymocyte globulin, CNI calcineurin inhibitor, DSA donor specific antibodies, D/R donor/recipient, + positive, - negative, HCMV human cytomegalovirus, IAS immunoadsorption, IQR interquartile range, n.a. not applicable, RTX renal transplantation
From: Cytomegalovirus in urinary sediment in patients with acute kidney injury
| Â | HCMV positive | HCMV negative | P-value |
|---|---|---|---|
Number of subjects | 10 | 38 | Â |
Age (years) | 56.1 ± 13.43 | 55.74 ± 12.82 | 0.938 |
Gender - number (%) | |||
 Male sex | 7 (70.00) | 26 (68.42) | 1.000 |
 Female sex | 3 (30.00) | 12 (31.58) | 1.000 |
Donor specific data | |||
 Donor Age (years) | 58.20 ± 17.33 | 55.44 ± 16.14 | 0.638 |
 Cold Ischemia Time (hours) | 17.56 ± 4.03 | 13.28 ± 5.68 | 0.031 |
 Deceased Donor - number (%) | 10 (100.00) | 32 (84.21) | 0.320 |
 Living Donor - number (%) | 0 (0.00) | 6 (15.79) | 0.320 |
Immunosuppression - number (%) | |||
 CNI-based Regimen | 7 (70.00) | 36 (94.74) | 0.054 |
 Belatacept-based Regimen | 3 (30.00) | 0 (0.00) | 0.007 |
 Other | 0 (0.00) | 2 (05.26) | 1.000 |
 History of ATG/IAS Induction Therapy | 0 (0.00) | 5 (13.16) | 0.569 |
 Rejection Therapy | 2 (20.00) | 9 (23.68) | 1.000 |
 Median time (IQR) after transplantation in days | 94 (51 – 596) | 17 (8 – 76) | 0.019 |
Baseline DSA - number (%) | |||
 positive | 0 (0.00) | 6 (15.79) | 0.320 |
 negative | 10 (100.00) | 32 (84.21) | 0.320 |
Allograft rejection - number (%) | |||
 yes | 2 (20.00) | 10 (26.32) | 1.000 |
 no | 8 (80.00) | 28 (73.68) | 1.000 |
Baseline HCMV status - number (%) | |||
 D-/R- | 0 (0.00) | 4 (10.53) | 0.567 |
 D-/R+ | 2 (20.00) | 13 (34.21) | 0.472 |
 D+/R- | 3 (30.00) | 5 (13.16) | 0.336 |
 D+/R+ | 5 (50.00) | 16 (42.10) | 0.729 |
HCMV- specific treatment at study timepoint - number (%) | |||
 yes | 3 (30.00) | 12 (31.58) | 1.000 |
 no | 7 (70.00) | 26 (68.42) | 1.000 |
HCMV infection at study timepoint - number (%) | |||
 yes | 1 (10.00) | 2 (05.26) | 0.512 |
 no | 9 (90.00) | 36 (94.74) | 0.512 |
History of HCMV infection within the previous 2 years - number (%) | |||
 yes | 2 (20.00) | 3 (07.89) | 0.276 |
 no | 8 (80.00) | 35 (92.11) | 0.276 |
HCMV infection during 8-months follow up - number (%) | |||
 yes | 1 (10.00) | 6 (15.79) | 1.000 |
 no | 9 (90.00) | 32 (84.21) | 1.000 |
Median (IQR) of HCMV urine sediment (copies/7mL urine) | 788 (552 – 928) | n.a. |  |