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Table 5 Comparison of the HAS-BLED score and prior major bleeding in predicting of future major bleeding event according to multivariable Cox proportional hazard models in the study population

From: Prior ischemic strokes are non-inferior for predicting future ischemic strokes than CHA2DS2-VASc score in hemodialysis patients with non-valvular atrial fibrillation

Variable

HR

95% CI

P value

HAS-BLED score

Crude

  HAS-BLED (↑ per unit)

0.89

0.63–1.27

0.53

Multivariable models

  1. Crude + INR

0.80

0.54–1.19

0.27

  2. 1 + Comorbidity index + Functional status

0.70

0.44–1.12

0.19

  3. 2 + Dual antiplatelet therapy + Kt/V + PPI use

0.76

0.47–1.20

0.24

  4. 3 + All-cause death

0.76

0.48–1.22

0.25

Prior Major Bleeding

Crude

  Prior Major Bleeding (yes)

2.30

1.00–5.27

0.05

Multivariable models

  1. Crude + INR

1.65

0.62–4.24

0.30

  2. 1 + Comorbidity index + Functional status

2.05

0.63–6.72

0.23

  3. 2 + Dual antiplatelet therapy + Kt/V + PPI use

2.10

0.67–6.59

0.20

  4. 3 + All-cause death

2.07

0.62–6.92

0.24

  1. Abbreviations: INR international normalized ratio, PPI proton-pump inhibitor