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Table 2 Comparison of clinical characteristics and laboratory data between the low serum FGF21 level group and high serum FGF21 level group in patients on HD

From: Fibroblast growth factor 21 (FGF21) is a sensitive marker of osteoporosis in haemodialysis patients: a cross-sectional observational study

 

Low FGF21 group

( FGF21 ≤ 184.50pg/ml )

High FGF21 group

( FGF21>184.50pg/ml )

P value

Number

170

169

 

General data

  Age(years)

55.82 ± 15.60

57.76 ± 15.59

0.253

  Sex(male %)

100(58.82 %)

93(55.03 %)

0.481

  Dialysis vintage(years)

4.17 ± 4.45

4.49 ± 5.35

0.540

  Body mass index(BMI)

22.93 ± 3.93

23.05 ± 4.09

0.794

  Systolic BP(mmHg)

145.75 ± 24.91

145.82 ± 23.95

0.979

  Diastolic BP(mmHg)

82.39 ± 13.95

82.25 ± 15.27

0.933

Blood data

  Hemoglobin(g/L)

99.92 ± 19.80

95.21 ± 20.07

0.031*

  Albumin(g/L)

36.80 ± 6.39

34.98 ± 5.74

0.006**

  Uric acid(mmol/L)

379.78 ± 134.65

377.50 ± 116.68

0.868

  Triglycerides(mmol/L)

1.75 ± 1.39

1.88 ± 1.35

0.412

  Total cholesterol(mmol/L)

4.19 ± 1.11

4.08 ± 1.13

0.346

  Dicarbonate(mmol/L)

23.06 ± 3.74

22.24 ± 3.74

0.044*

  Calcium(mmol/L)

2.27 ± 0.24

2.26 ± 0.24

0.639

  Phosphate(mmol/L)

1.73 ± 0.56

1.75 ± 0.61

0.744

  Parathormon(pg/ml)

369.08 ± 452.80

379.08 ± 383.00

0.826

CT

  L1 attenuation (HU)

168.90 (137.75, 197.00)

159.10 (118.15, 212.00)

0.363

Comorbidity

  Diabetes(%)

60(35.29 %)

50(29.59 %)

0.262

  Hypertension(%)

155(91.18 %)

141(83.43 %)

0.032*

  CVD(%)

43(25.29 %)

34(20.12 %)

0.255

Medicine usage

  Vitamin D(%)

76(44.71 %)

75(44.38 %)

0.952

  Calciu supplements(%)

41(24.12 %)

45(26.63 %)

0.595

  Cinacalcet(%)

31(18.24 %)

21(12.43 %)

0.138

  ACEI/ARB(%)

52(30.59 %)

42(24.85 %)

0.238

FRAX(306) a

  Major Osteoporosis

3.78 ± 2.56

3.64 ± 2.70

0.637

  Hip fracture

1.61 ± 1.85

1.57 ± 2.04

0.881

  1. The values are shown as the mean ± SD, median (interquartile range) or numbers (%), *P<0.05, **P<0.01.
  2. a306 of 339 patients agreed to complete the FRAX questionnaire.
  3. HD haemodialysis; BP blood pressure; FGF21 fibroblast growth factor 21; HU hounsfield unit; CVD cardiocerebrovascular disease; ACEI angiotensin-converting enzyme; ARB angiotensin receptor II antagonist; FRAX fracture risk assessment tool