Variables | N = 151 |
---|---|
Demographic characteristics | |
Age (years) | 56 ± 13 |
Male gender (%) | 101 (67) |
Body mass index (kg/m2) | 25.6 ± 3.9 |
Original kidney disease | |
diabetic glomerulosclerosis (%) | 8 (5) |
hypertension (%) | 9 (6) |
glomerulonephritis (%) | 56 (37) |
polycystic (%) | 19 (13) |
pyelonephritis/reflux (%) | 14 (9) |
other/undefined (%) | 16 (11) / 29 (19) |
Clinical characteristics | |
Time post-transplant (years) | 8.1 (3.1 to 12.9) |
Prior indication allograft biopsya (%) | 76 (50) |
Histological diagnosis | |
antibody-mediated rejection (%) | 30 (40) |
T-cell rejection (%) | 22 (29) |
recurrent glomerular disease (%) | 7 (9) |
other findingsb (%) | 17 (22) |
De-novo donor-specific antibodiesc (%) | 28 (19) |
Vital parameters | |
systolic blood pressure (mmHg) | 136 ± 17 |
diastolic blood pressure (mmHg) | 76 ± 11 |
heart rate (beats/min) | 74 ± 13 |
Medication | |
ACEi/ARB (%) | 138 (91) |
diuretic | 49 (32) |
other antihypertensives | 135 (89) |
lipid-lowering treatments | 96 (64) |
glucose-lowering treatments | 37 (25) |
calcineurin inhibitor | 151 (100) |
mycophenolate | 126 (83) |
steroid | 83 (55) |
Laboratory parameters | |
First morning urine collection | |
protein-to-creatinine ratio (mg/mmol) | 52 (31 to 124) |
albumin-to-creatinine ratio (mg/mmol) | 18 (6 to 76) |
α-1 microglobulin-to-creatinine ratio (mg/mmol) | 4.2 (2.3 to 6.8) |
Second morning urine collection | |
protein-to-creatinine ratio (mg/mmol) | 52 (29 to 124) |
albumin-to-creatinine ratio (mg/mmol) | 22 (6 to 74) |
α-1 microglobulin-to-creatinine ratio (mg/mmol) | 4.1 (2.2 to 7.2) |
24-h urine collection | |
protein (mg/day/1.73m2) | 490 (250 to 1160) |
creatinine clearance (ml/min) | 51 ± 23 |
Serum | |
creatinine | 127 ± 48 |
eGFR (ml/min/1.73m2) | 53 ± 19 |
total cholesterol (mmol/L) | 4.9 ± 1.1 |
LDL cholesterol (mmol/L) | 2.8 ± 0.8 |
HDL cholesterol (mmol/L) | 1.3 ± 0.5 |
triglycerides (mmol/L) | 1.9 ± 1.2 |
calcium (mmol/L) | 2.33 ± 0.14 |
phosphate (mmol/L) | 0.98 ± 0.23 |
albumin | 43 ± 3 |