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Table 3 Association of rs35767 genotype with HbA1c, UA, and eGFR according to sex

From: Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study

 

HbA1c

UA

eGFR

Model

1(M)

2(F)

3(All)

1(M)

2(F)

3(All)

1(M)

2(F)

3(All)

 

β (SE)

p

β (SE)

p

β

(SE)

p

β

(SE)

p

β

(SE)

p

β

(SE)

p

β

(SE)

p

β

(SE)

p

β

(SE)

p

CC

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

TC

−0.01 (0.02)

0.89

0.01 (0.05)

0.95

− 0.01 (0.02)

0.86

−0.03 (0.07)

0.65

0.02 (0.12)

0.89

0.03 (0.06)

0.61

0.19 (0.86)

0.83

1.67 (3.00)

0.58

0.29 (0.86)

0.73

TT

−0.05 (0.03)

0.13

−0.09 (0.07)

0.19

−0.06 (0.03)

0.05

0.05 (0.10)

0.61

0.04 (0.19)

0.81

0.10 (0.10)

0.32

1.99 (1.35)

0.14

1.70 (4.71)

0.72

2.06 (1.35)

0.12

  1. Model 1, males only (M); Model 2, females only (F); Model 3, males and females (All); all models adjusted for age, BMI, MBP, eGFR, UA, LDLC, HbA1c
  2. n = 1506 (F/M, 206/1300)
  3. Abbreviations: HbA1c glycated hemoglobin, UA uric acid, eGFR estimated glomerular filtration rate, BMI body mass index, LDLC low-density lipoprotein cholesterol, MBP mean blood pressure, β regression coefficients, ref. reference, SE standard error