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Table 4 Longitudinal analysis of factors to explain the decline in eGFRa

From: Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study

Objective variable

⊿eGFR in 10 years

 

All

Younger age

Older age

 

β

(SE)

t value

p value

β

(SE)

t value

p value

β

(SE)

t value

p value

BMI

−0.01 (0.11)

−0.08

0.94

−0.17 (0.17)

−0.98

0.32

0.01 (0.15)

0.05

0.96

MBP

−0.06 (0.03)

−1.97

< 0.05

−0.06 (0.05)

−1.26

0.20

−0.05 (0.04)

−1.36

0.18

UA

1.17 (0.28)

4.12

< 0.05

1.69 (0.44)

3.84

< 0.05

0.59 (0.37)

1.60

0.11

HbA1c

−2.30 (0.57)

−4.07

< 0.05

2.22 (1.77)

1.25

0.21

−2.83 (0.60)

−4.70

< 0.05

rs35767 polymorphism

 CC

Ref

  

Ref

  

Ref

  

 TC

−0.19 (0.67)

−0.28

0.78

−0.99 (0.96)

−1.03

0.31

0.71 (0.93)

0.77

0.44

 TT

−2.42 (1.06)

−2.28

< 0.05

−3.90 (1.53)

−2.55

< 0.05

−1.02 (1.47)

−0.70

0.49

  1. an = 1506 individuals who were followed up for 10 years (F/M = 206/1300)
  2. Younger age (18-32y.o.), n = 768 (F/M 168/600)
  3. Older age (33-55y.o.), n = 738 (F/M = 38/700)
  4. Model includes sex, age, BMI, MBP, UA, HbA1c, and rs35767 genotype