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Table 4 Longitudinal analysis of factors to explain the decline in eGFRa

From: Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study

Objective variable eGFR in 10 years
  All Younger age Older age
  β
(SE)
t value p value β
(SE)
t value p value β
(SE)
t value p value
BMI −0.01 (0.11) −0.08 0.94 −0.17 (0.17) −0.98 0.32 0.01 (0.15) 0.05 0.96
MBP −0.06 (0.03) −1.97 < 0.05 −0.06 (0.05) −1.26 0.20 −0.05 (0.04) −1.36 0.18
UA 1.17 (0.28) 4.12 < 0.05 1.69 (0.44) 3.84 < 0.05 0.59 (0.37) 1.60 0.11
HbA1c −2.30 (0.57) −4.07 < 0.05 2.22 (1.77) 1.25 0.21 −2.83 (0.60) −4.70 < 0.05
rs35767 polymorphism
 CC Ref    Ref    Ref   
 TC −0.19 (0.67) −0.28 0.78 −0.99 (0.96) −1.03 0.31 0.71 (0.93) 0.77 0.44
 TT −2.42 (1.06) −2.28 < 0.05 −3.90 (1.53) −2.55 < 0.05 −1.02 (1.47) −0.70 0.49
  1. an = 1506 individuals who were followed up for 10 years (F/M = 206/1300)
  2. Younger age (18-32y.o.), n = 768 (F/M 168/600)
  3. Older age (33-55y.o.), n = 738 (F/M = 38/700)
  4. Model includes sex, age, BMI, MBP, UA, HbA1c, and rs35767 genotype