Fig. 4
From: Anti-fibrotic potential of erythropoietin signaling on bone marrow derived fibrotic cell
EPO signaling inhibited the accumulation of CD45+/αSMA + cells in mouse UUO model. The number of CD45+/αSMA + cells was analyzed by immunofluorescent staining. The dual positive cells for CD45+/αSMA + were accumulated in mouse UUO model. The administration of EPO inhibited the accumulation of CD45+/αSMA + cells (a, b). Nevertheless, compared with the PBS-administered group, hydroxyproline content did not differ in the UUO kidneys of C57BL/6 mice in the EPO-administered group (c). (Scale bars : 20 μm.)