Table 2 Pathologic scoring of kidney biopsy specimens from 135 patients with DKD
From: Modified arteriosclerosis score predicts the outcomes of diabetic kidney disease
Pathologic scores | Pathologic definitions | Prevalence, n (%) |
|---|---|---|
RPS Glomerular class | ||
 I | Mild | 1 (0.7%) |
 IIa | Mild mesangial expansion in > 25% of mesangium | 15 (10.2%) |
 IIb | Severe mesangial expansion in > 25% of mesangium | 17 (11.6%) |
 III | At least one KW lesion | 86 (58.5%) |
 IV | Advanced diabetic glomerulosclerosis | 16 (10.9%) |
IFTA | ||
 0 | None | 0 (0%) |
 1 | 1–25% | 25 (18.5%) |
 2 | 26–50% | 45 (33.3%) |
 3 | > 50 | 65 (48.2%) |
Interstitial inflammation | ||
 0 | None | 0 (0%) |
 1 | Infiltration only in relation to IFTA | 88 (65.2%) |
 2 | Infiltration in areas without IFTA | 47 (34.8%) |
Arteriolar hyalinosis score | ||
 0 | Absent | 3(2.2%) |
 1 | At least one area of arteriolar hyalinosis | 12(8.9%) |
 2 | More than one area of arteriolar hyalinosis | 120(88.9) |
Modified arteriolar hyalinosis score | ||
 0 | Absent | 3(2.2%) |
 1 | Mild-to-moderate PAS-positive hyaline thickening in at least one arteriole | 12(8.9%) |
 2 | moderate-to-severe PAS-positive hyaline thickening in more than one arteriole | 49(36.3%) |
 3 | Severe PAS-positive hyaline thickening in many arterioles | 71(52.6%) |
Arteriosclerosis scorea | ||
 0 | No intimal thickening | 0(0%) |
 1 | Intimal thickening less than thickness of media | 63(46.7%) |
 2 | Intimal thickening greater than thickness of media | 72(53.3%) |
Modified arteriosclerosis score b | ||
 1 | 0–49% The Proportion of arteries with intima thickness greater than media thickness in the biopsy | 113(83.7%) |
 2 | ≥50% | 22(16.3%) |