Modified arteriosclerosis score predicts the outcomes of diabetic kidney disease

Table 4 Univariate and multivariable models for time to outcome (endpoint:ESRD or death)

Characteristics	Univariate Model HR (95% CI)	P Value	Pathological Model HR (95% CI)	P Value	Fully Risk-Adjustment Model HR (95% CI)	P Value
Clinical features
Alb
Baseline Urine protein					1.10(1.04–1.16)	0.00
Baseline eGFR					0.97(0.95–0.98)	0.00
Pathological features
RPS Glomerular class	2.24(1.47–3.40)	0.00	1.68(1.13–2.50)	0.01
IFTA	2.44(1.61–3.69)	0.00	1.83(1.18–2.84)	0.01
Interstitial inflammation	1.59(0.96–2.62)	0.07
Arteriosclerosis score	2.14(1.26–3.63)	0.01
Modified Arteriosclerosis score	4.15(2.35–7.36)	0.00	1.44(1.04–1.99)	0.03
Arteriolar hyalinosis score	2.43(0.81–7.34)	0.12
Modified Arteriolar hyalinosis score	1.15(0.79–1.67)	0.46
GBM thickness	1.00(0.99–1.00)	0.86

Pathological model: RPS, IFTA and Modified arteriosclerosis score; The fully risk-adjustment model: clinical features (eGFR, proteinuria, albumin) and RPS class, IFTA, Modified arteriosclerosis score
Abbreviations: Alb albumin, CI confidence interval, eGFR estimated glomerular filtration rate, ESRD end-stage renal disease, GBM glomerular basement membrane, IFTA interstitial fibrosis and tubular atrophy, RPS the Renal Pathology Society