Oral sodium bicarbonate in people on haemodialysis: a randomised controlled trial

BMC Nephrology

Table 4 Electrocardiogram changes in intervention and control groups

		No treatment		Week 5-8			Week 13-16			Final dose
		Mean	SD	Mean	SD	p value^a	Mean	SD	p value^a	Mean	SD	p value^b
Intervention (N = 16)
Heart rate (s-1)	Pre HD	70.2	15.5	71.8	12.4	0.18	73.8	14.1	0.83	73.0	13.8	0.98
	Post HD	76.5	12.3	75.5	13.1	0.22	76.6	14.7	0.59	76.2	13.7	0.24
	HD effect	+ 6.3	8.8	+ 3.6	9.8	0.83	+ 2.8	9.7	0.63	+ 3.2	9.2	0.15
PR interval	Pre HD	173	34	177	42	0.97	173	35	0.60	175	36	0.99
	Post HD	163	29	169	34	0.89	162	25	0.44	165	28	0.33
	HD effect	−9.9	19.7	−7.8	14.7	0.93	−11.5	21.0	0.74	−9.6	16.8	0.94
QRS duration	Pre HD	94	17	92	14	0.95	94	16	0.93	94	16	0.69
	Post HD	97	15	94	15	0.86	96	16	0.73	96	16	0.89
	HD effect	+ 3.3	8.9	+ 2.3	5.3	0.71	+ 2.8	8.4	0.58	+ 2.6	8.0	0.62
Corrected QT	Pre HD	428	31	429	22	0.08	429	19	0.21	429	19	0.46
	Post HD	437	30	438	38	0.38	441	31	0.29	439	31	0.51
	HD effect	+ 8.8	22.4	+ 9.1	27.1	0.51	+ 11.7	28.8	0.71	+ 10.4	27.9	0.79
QT dispersion	Pre HD	35	15	34	12	0.83	41	13	0.36	40	12	0.44
	Post HD	38	13	33	12	0.96	34	12	0.48	34	12	0.12
	HD effect	+ 3.2	15.9	−1.7	12.6	0.88	−7.3	13.6	0.18	−5.7	13.9	0.18
Control (N = 20)
Heart rate (s-1)	Pre HD	73.0	16.2	74.7	13.6		71.4	12.9
	Post HD	81.7	17.1	78.9	14.8		76.6	14.8
	HD effect	+ 8.7	12.0	+ 4.2	10.5		+ 5.2	11.1
PR interval	Pre HD	179	39	174	44		179	40
	Post HD	166	42	169	47		169	38
	HD effect	−13.6	16.4	−5.7	13.9		−9.9	11.5
QRS duration	Pre HD	92	18	93	18		95	21
	Post HD	95	19	95	21		98	18
	HD effect	+ 3.7	4.6	+ 2.4	6.4		+ 3.7	7.3
Corrected QT	Pre HD	437	52	437	22		431	16
	Post HD	446	34	443	30		446	28
	HD effect	+ 8.9	44.6	+ 5.7	25.6		+ 14.9	20.8
QT dispersion	Pre HD	36	12	35	12		36	12
	Post HD	37	15	32	13		36	14
	HD effect	+ 0.2	15.6	−3.9	13.0		−0.4	16.2

ISSN: 1471-2369