Table 2 Incident cases of register-based chronic kidney disease in relation to growth differentiation factor-15 (GDF-15)

GDF-15 range male (AU)

6.09-8.47

8.47-8.82

8.82-9.21

9.21-11.2

–

GDF-15 range female (AU)

6.78-8.35

8.35-8.66

8.66-9.02

9.02-12.3

–

No. of subjects

1080

1079

1080

1079

–

–

–

Incidence ^b

16

31

43

75

–

–

–

Incidence (per 1000 person-years)

0.74

1.45

2.08

3.93

–

–

Model 1 ^{c d}

Reference

2.08 (1.14, 3.81)

3.15 (1.77, 5.60)

6.58 (3.82, 11.3)

< 0.0001

1.97 (1.75, 2.22)

< 0.0001

Model 2 ^{c e}

Reference

1.66 (0.90, 3.04)

1.98 (1.10, 3.56)

3.46 (1.97, 6.10)

< 0.0001

1.81 (1.56, 2.10)

< 0.0001

Model 3 ^{c f}

Reference

1.56 (0.85, 2.86)

1.66 (0.91, 3.00)

2.74 (1.53, 4.89)

< 0.001

1.51 (1.27, 1.80)

< 0.0001

Model 4 ^{c g}

Reference

1.57 (0.85, 2.88)

1.62 (0.90, 2.92)

2.37 (1.33, 4.24)

< 0.01

1.39 (1.16, 1.65)

< 0.001