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Table 2 Univariable and multivariable Cox proportional hazard model analyses for KF from all other and Atheroembolic KF

From: Burden of kidney failure from atheroembolic disease and association with survival in people receiving dialysis in Australia and New Zealand: a multi-centre registry study

Characteristics

UNIVARIATE

MULTIVARIATE

HR

95% CI

p-value

HR

95% CI

p-value

All other KF

Ref

  

Ref

  

KF from Atheroembolic Disease

1.80

1.61–2.03

< 0.001

0.93

0.82–1.05

0.24

Age per decade at cohort entry

1.41

1.40–1.43

< 0.001

1.43

1.42–1.45

< 0.001

Male sex

1.04

1.01–1.06

< 0.001

0.95

093–0.97

< 0.001

Primary kidney disease

  

< 0.001

   

 Diabetic nephropathy

Ref

     

 Glomerulonephritis

0.56

0.55–0.58

< 0.001

   

 Reflux nephropathy

0.39

0.35–0.42

< 0.001

   

 Polycystic disease

0.42

0.40–0.45

< 0.001

   

 Hypertension

1.13

1.09–1.16

< 0.001

   

 Other

1.04

1.01–1.07

< 0.004

   

Racial origin

  

< 0.001

  

< 0.001

 Caucasian

Ref

  

Ref

  

 Other

0.75

0.73–0.76

< 0.001

0.83

0.81–0.85

< 0.001

BMI (kg/m2)

  

< 0.001

  

< 0.001

  < 18.5

1.25

1.18–1.32

< 0.001

1.43

1.35–1.52

< 0.001

 18.5–24.9

Ref

    

< 0.001

 25–29.9

0.94

0.92–0.97

< 0.001

0.88

0.86–0.90

< 0.001

  ≥ 30

0.84

0.82–0.86

< 0.001

0.85

0.82–0.87

< 0.001

Late referral

1.17

1.14–1.20

< 0.001

1.23

1.20–1.26

< 0.001

Comorbidities

 Diabetes

1.38

1.35–1.41

< 0.001

1.46

1.43–1.50

< 0.001

 CAD

1.86

1.82–1.90

< 0.001

1.30

1.28–1.34

< 0.001

 PVD

1.89

1.85–1.94

< 0.001

1.32

1.28–1.35

< 0.001

 Chronic lung disease

1.64

1.60–1.69

< 0.001

1.30

1.26–1.34

< 0.001

 Cerebrovascular disease

1.74

1.65–1.75

< 0.001

1.20

1.17–1.24

< 0.001

Current smoking

0.97

0.94–1.00

0.06

1.26

1.22–1.30

< 0.001

Dialysis eras (years)

  

< 0.001

  

< 0.001

 1990–1998

1.22

1.19–1.26

< 0.001

1.30

1.26–1.35

< 0.001

 1999–2007

Ref

     

 2008–2017

0.88

0.86–0.90

< 0.001

0.85

0.83–0.87

< 0.001

Modality

  

< 0.001

  

< 0.001

 HD

Ref

     

 HHD

0.22

0.14–0.35

< 0.001

0.31

0.19–0.50

< 0.001

 PD

1.04

1.02–1.07

< 0.001

1.03

1.01–1.06

0.01

Country

 Australia

Ref

     

 New Zealand

1.09

1.06–1.12

< 0.001

1.44

1.39–1.48

< 0.001

  1. Multivariable analysis adjusted for: disease group (atheroembolic vs all other KF), age, gender, racial origin (Caucasian vs other), sub-era, kidney replacement modality, late referral, current smoking, body mass index, comorbidities at entry (diabetes mellitus, coronary artery disease, peripheral vascular disease, chronic lung disease and cerebrovascular disease) and country (Australia vs New Zealand)
  2. 95% CI 95% confidence interval, BMI Body Mass Index, CAD Coronary Artery Disease, CVD Composite Cardiovascular Disease, HD Hemodialysis, HHD Home Hemodialysis, HR Hazard Ratio, N Number, PD Peritoneal Dialysis, PVD Peripheral Vascular Disease, Ref Reference