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Fig. 3 | BMC Nephrology

Fig. 3

From: A novel de novo truncating TRIM8 variant associated with childhood-onset focal segmental glomerulosclerosis without epileptic encephalopathy: a case report

Fig. 3

Immunofluorescence staining using anti-TRIM8 antibody. Immunofluorescence staining of the kidney specimen, using an anti-TRIM8 antibody; (A) normal control, (F) the present patient, combined with anti-podocalyxin antibody, (B) normal control, (G) the present patient; anti-CD34 antibody, (C) normal control, (H) the present case; anti-CD10 antibody (D) normal control, (I) the present patient; and anti-EMA antibody (E) normal control, (J) the present patient (original magnification × 400. Scale bar = 50 µm). TRIM8 was expressed in the nuclei of podocytes (podocalyxin-positive cells, B) (arrowheads) and endothelial cells (CD34-positive cells, C) (arrows). Proximal and distal tubular epithelial cells also showed the nuclear expression of TRIM8 protein in the normal control specimen (D and E). TRIM8 expression was not observed in any cells in the kidney tissue obtained from the present patient (F–J). Tubules with cystic dilatation were positive for EMA but negative for CD10 (I and J).CD10, Cluster of differentiation 10; CD34, Cluster of differentiation 34; EMA, epithelial membrane antigen; TRIM8, tripartite motif containing 8

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BMC Nephrology

ISSN: 1471-2369

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