Variables | Total (n = 73) | Pre-existing LN (n = 38) | New-onset LN (n = 35) | P value |
---|---|---|---|---|
Age, years | 28.0 (25.0, 31.0) | 29.0 (26.0, 32.0) | 26.0 (23.0, 29.5) | 0.011 |
Body mass index, kg/m2 | 25.2 (23.4, 26.6) | 24.7 (23.7, 27.9) | 25.4 (23.3, 26.0) | 0.71 |
Systolic blood pressure, mmHg | 126.0 (112.0, 139.0) | 129.0 (119.5, 142.0) | 124.0 (110.0, 138.0) | 0.25 |
Diastolic blood pressure, mmHg | 80.0 (70.0, 90.0) | 81.5 (71.5, 90.5) | 75.5 (69.5, 92.5) | 0.38 |
Mean arterial pressure, mmHg | 94.3 (83.7, 106.7) | 98.8 (87.8, 107.7) | 90.7 (83.5, 107.8) | 0.34 |
History of pregnancy | ||||
First-time pregnancy (%) | 33 (45.2) | 17 (44.7) | 16 (45.7) | 0.82 |
Adverse pregnancy history (%) | 20 (27.4) | 12 (31.63) | 8 (22.9) | 0.62 |
Duration of SLE diagnosis to pregnancy, years | - | 7 (4.0, 10.0) | - | - |
Duration of LN diagnosis to pregnancy, years | - | 6 (2.0, 9.3) | - | - |
Treatment during pregnancy (%) | ||||
Prednisone and immunosuppressant | 11 (15.1) | 10 (26.3) | 1 (2.9) | 0.007 |
Prednisone alone | 65 (89.0) | 35 (92.1) | 30 (85.7) | 0.28 |
Treatment post pregnancy (%) | ||||
Prednisone and cyclophosphamide | 20 (27.4) | 9 (23.7) | 11 (31.4) | 0.40 |
Prednisone and methotrexate | 5 (6.8) | 1 (2.6) | 4 (11.4) | 0.18 |
Prednisone and calcineurin inhibitors | 9 (12.3) | 6 (15.8) | 3 (8.6) | 0.48 |
Prednisone and mycophenolate mofetil | 8 (11.1) | 4 (10.5) | 4 (11.4) | 0.86 |
Laboratory Values | ||||
Hemoglobin, g/L | 91.0 (76.0, 108.0) | 98.0 (81.0, 112.0) | 85.0 (75.5, 103.5) | 0.12 |
Platelet, ×109/L | 179.0 (134.0, 257.0) | 203.0 (137.0, 260.0) | 173.0 (123.0, 239.0) | 0.63 |
White blood cell, ×109/L | 7.8 (5.5, 9.9) | 8.8 (7.0, 10.8) | 5.8 (4.3, 9.3) | 0.012 |
Urea nitrogen, mg/dL | 35.5 (21.0, 54.1) | 34.9 (22.8, 55.9) | 35.5 (19.8, 47.5) | 0.64 |
Serum creatinine, mg/dL | 0.8 (0.6, 1.1) | 0.7 (0.6, 1.2) | 0.8 (0.6, 1.1) | 0.51 |
eGFR, mL/min/1.73 m2 | 106.0 (67.4, 124.9) | 103.6 (63.6, 125.1) | 108.5 (71.2, 124.9) | 0.79 |
Serum albumin, g/dL | 2.5 (2.1, 2.9) | 2.3 (1.9, 2.9) | 2.5 (2.2, 2.7) | 0.44 |
Proteinuria, g/day | 3.8 (2.0, 6.0) | 4.5 (2.8, 5.1) | 3.8 (2.0, 6.5) | 0.93 |
> 3 red blood cells / high-power field (%) | 49 (67.1) | 24 (63.2) | 25 (71.4) | 0.29 |
> 5 white blood cells/ high-power field (%) | 46 (63.0) | 21 (55.3) | 25 (71.4) | 0.25 |