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Table 1 Clinical characteristics at the time of delivery

From: Fetal and maternal outcome in patients with active lupus nephritis: comparison between new-onset and pre-existing lupus nephritis

Variables

Total (n = 73)

Pre-existing LN (n = 38)

New-onset LN (n = 35)

P value

Age, years

28.0 (25.0, 31.0)

29.0 (26.0, 32.0)

26.0 (23.0, 29.5)

0.011

Body mass index, kg/m2

25.2 (23.4, 26.6)

24.7 (23.7, 27.9)

25.4 (23.3, 26.0)

0.71

Systolic blood pressure, mmHg

126.0 (112.0, 139.0)

129.0 (119.5, 142.0)

124.0 (110.0, 138.0)

0.25

Diastolic blood pressure, mmHg

80.0 (70.0, 90.0)

81.5 (71.5, 90.5)

75.5 (69.5, 92.5)

0.38

Mean arterial pressure, mmHg

94.3 (83.7, 106.7)

98.8 (87.8, 107.7)

90.7 (83.5, 107.8)

0.34

History of pregnancy

    

First-time pregnancy (%)

33 (45.2)

17 (44.7)

16 (45.7)

0.82

Adverse pregnancy history (%)

20 (27.4)

12 (31.63)

8 (22.9)

0.62

Duration of SLE diagnosis to pregnancy, years

-

7 (4.0, 10.0)

-

-

Duration of LN diagnosis to pregnancy, years

-

6 (2.0, 9.3)

-

-

Treatment during pregnancy (%)

    

Prednisone and immunosuppressant

11 (15.1)

10 (26.3)

1 (2.9)

0.007

Prednisone alone

65 (89.0)

35 (92.1)

30 (85.7)

0.28

Treatment post pregnancy (%)

    

Prednisone and cyclophosphamide

20 (27.4)

9 (23.7)

11 (31.4)

0.40

Prednisone and methotrexate

5 (6.8)

1 (2.6)

4 (11.4)

0.18

Prednisone and calcineurin inhibitors

9 (12.3)

6 (15.8)

3 (8.6)

0.48

Prednisone and mycophenolate mofetil

8 (11.1)

4 (10.5)

4 (11.4)

0.86

Laboratory Values

    

Hemoglobin, g/L

91.0 (76.0, 108.0)

98.0 (81.0, 112.0)

85.0 (75.5, 103.5)

0.12

Platelet, ×109/L

179.0 (134.0, 257.0)

203.0 (137.0, 260.0)

173.0 (123.0, 239.0)

0.63

White blood cell, ×109/L

7.8 (5.5, 9.9)

8.8 (7.0, 10.8)

5.8 (4.3, 9.3)

0.012

Urea nitrogen, mg/dL

35.5 (21.0, 54.1)

34.9 (22.8, 55.9)

35.5 (19.8, 47.5)

0.64

Serum creatinine, mg/dL

0.8 (0.6, 1.1)

0.7 (0.6, 1.2)

0.8 (0.6, 1.1)

0.51

eGFR, mL/min/1.73 m2

106.0 (67.4, 124.9)

103.6 (63.6, 125.1)

108.5 (71.2, 124.9)

0.79

Serum albumin, g/dL

2.5 (2.1, 2.9)

2.3 (1.9, 2.9)

2.5 (2.2, 2.7)

0.44

Proteinuria, g/day

3.8 (2.0, 6.0)

4.5 (2.8, 5.1)

3.8 (2.0, 6.5)

0.93

> 3 red blood cells / high-power field (%)

49 (67.1)

24 (63.2)

25 (71.4)

0.29

> 5 white blood cells/ high-power field (%)

46 (63.0)

21 (55.3)

25 (71.4)

0.25

  1. Data are presented as median (range) or as number (percentage). The p-values of categorical variable obtained with the Chi square or Fisher's exact test and continuous variables obtained with the Mann Whitney U-test.
  2. LN lupus nephritis, SLE systemic lupus erythematosus, eGFR estimated glomerular filtration rate