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Table 1 Clinical characteristics at the time of delivery

From: Fetal and maternal outcome in patients with active lupus nephritis: comparison between new-onset and pre-existing lupus nephritis

Variables Total (n = 73) Pre-existing LN (n = 38) New-onset LN (n = 35) P value
Age, years 28.0 (25.0, 31.0) 29.0 (26.0, 32.0) 26.0 (23.0, 29.5) 0.011
Body mass index, kg/m2 25.2 (23.4, 26.6) 24.7 (23.7, 27.9) 25.4 (23.3, 26.0) 0.71
Systolic blood pressure, mmHg 126.0 (112.0, 139.0) 129.0 (119.5, 142.0) 124.0 (110.0, 138.0) 0.25
Diastolic blood pressure, mmHg 80.0 (70.0, 90.0) 81.5 (71.5, 90.5) 75.5 (69.5, 92.5) 0.38
Mean arterial pressure, mmHg 94.3 (83.7, 106.7) 98.8 (87.8, 107.7) 90.7 (83.5, 107.8) 0.34
History of pregnancy     
First-time pregnancy (%) 33 (45.2) 17 (44.7) 16 (45.7) 0.82
Adverse pregnancy history (%) 20 (27.4) 12 (31.63) 8 (22.9) 0.62
Duration of SLE diagnosis to pregnancy, years - 7 (4.0, 10.0) - -
Duration of LN diagnosis to pregnancy, years - 6 (2.0, 9.3) - -
Treatment during pregnancy (%)     
Prednisone and immunosuppressant 11 (15.1) 10 (26.3) 1 (2.9) 0.007
Prednisone alone 65 (89.0) 35 (92.1) 30 (85.7) 0.28
Treatment post pregnancy (%)     
Prednisone and cyclophosphamide 20 (27.4) 9 (23.7) 11 (31.4) 0.40
Prednisone and methotrexate 5 (6.8) 1 (2.6) 4 (11.4) 0.18
Prednisone and calcineurin inhibitors 9 (12.3) 6 (15.8) 3 (8.6) 0.48
Prednisone and mycophenolate mofetil 8 (11.1) 4 (10.5) 4 (11.4) 0.86
Laboratory Values     
Hemoglobin, g/L 91.0 (76.0, 108.0) 98.0 (81.0, 112.0) 85.0 (75.5, 103.5) 0.12
Platelet, ×109/L 179.0 (134.0, 257.0) 203.0 (137.0, 260.0) 173.0 (123.0, 239.0) 0.63
White blood cell, ×109/L 7.8 (5.5, 9.9) 8.8 (7.0, 10.8) 5.8 (4.3, 9.3) 0.012
Urea nitrogen, mg/dL 35.5 (21.0, 54.1) 34.9 (22.8, 55.9) 35.5 (19.8, 47.5) 0.64
Serum creatinine, mg/dL 0.8 (0.6, 1.1) 0.7 (0.6, 1.2) 0.8 (0.6, 1.1) 0.51
eGFR, mL/min/1.73 m2 106.0 (67.4, 124.9) 103.6 (63.6, 125.1) 108.5 (71.2, 124.9) 0.79
Serum albumin, g/dL 2.5 (2.1, 2.9) 2.3 (1.9, 2.9) 2.5 (2.2, 2.7) 0.44
Proteinuria, g/day 3.8 (2.0, 6.0) 4.5 (2.8, 5.1) 3.8 (2.0, 6.5) 0.93
> 3 red blood cells / high-power field (%) 49 (67.1) 24 (63.2) 25 (71.4) 0.29
> 5 white blood cells/ high-power field (%) 46 (63.0) 21 (55.3) 25 (71.4) 0.25
  1. Data are presented as median (range) or as number (percentage). The p-values of categorical variable obtained with the Chi square or Fisher's exact test and continuous variables obtained with the Mann Whitney U-test.
  2. LN lupus nephritis, SLE systemic lupus erythematosus, eGFR estimated glomerular filtration rate