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Table 2 Immunological parameters at the time of delivery

From: Fetal and maternal outcome in patients with active lupus nephritis: comparison between new-onset and pre-existing lupus nephritis

Variables Total (n = 73) Pre-existing LN
(n = 38)
New-onset LN
(n = 35)
P value
ESR, mm/h 37.0 (18.0, 47.0) 40.0 (18.0, 49.0) 34.0 (23.0, 43.0) 0.41
Anti-dsDNA antibodies, U/ml 4.5 (2.6, 83.0) 5.5 (2.3, 95.0) 4.4 (2.7, 20.0) 0.64
Anti-dsDNA antibody positive (%) 65 (89.0) 32 (84.2) 33 (94.3) 0.41
ANA positive (%) 69 (94.5) 34 (89.5) 35 (100) 0.16
Antiphospholipid antibody positivity (%) * 15 (20.5) 4 (10.5) 11 (31.4) 0.027
Anti-cardiolipin IgG positivity (%) 8 (11.0) 2 (5.3) 6 (17.1) 0.14
Anti-cardiolipin IgM positivity (%) 7 (9.6) 1 (2.6) 6 (17.1) 0.035
β2 glycoproteins positive, n (%) 5 (6.8) 1 (2.6) 4 (11.4) 0.19
Anti-SSA antibody positive (%) 40 (54.8) 16 (42.1) 24 (68.6) 0.11
Anti-SSB antibody positive (%) 12 (16.4) 4 (10.5) 8 (22.9) 0.34
Anti-Sm antibody positive (%) 19 (26.0) 6 (15.8) 13 (37.1) 0.10
Anti-rRNP antibody positive (%) 31 (42.5) 11 (28.9) 20 (57.1) 0.04
Complement C3, mg/dl 0.5 (0.4 0.8) 0.6 (0.5, 0.9) 0.4 (0.3, 0.6) < 0.01
Complement C4, mg/dl 0.1 (0.1, 0.1) 0.1 (0.1, 0.2) 0.1 (0.1, 0.1) 0.02
Low complement C3 (%) 54 (74.0) 23 (60.5) 31 (88.6) 0.006
Low complement C4 (%) 55 (75.3) 23 (60.5) 32 (91.4) 0.002
  1. Data are presented as median (range) or as number (percentage). The p-values of categorical variable obtained with the Chi square or Fisher's exact test and continuous variables obtained with the Mann Whitney U-test.
  2. LN lupus nephritis, ESR erythrocyte sedimentation rate, anti-dsDNA anti-double-stranded DNA, ANA anti-nuclear antibody, SSA Sjögren syndrome antigen A, SSB Sjögren syndrome antigen B, rRNP ribosomal ribonucleoprotein
  3. *Data on 21 cases were unavailable and lupus anticoagulant was not studied.