Table 1 Demographic and clinical characteristics of 80 CRS1 patients according to allocation group
All patients n = 80 | Stepped Furosemide n = 40 | Combined Diuretics n = 40 | p | |
|---|---|---|---|---|
Male (%) | 37 (46.2) | 19 (47.5) | 18 (45) | 0.82 |
Age (years) | 59 ± 14.5 | 58 ± 14.5 | 59 ± 14.6 | 0.73 |
Comorbidities | ||||
Diabetes (%) | 55 (71.4) | 25 (64.1) | 30 (78.9) | 0.15 |
Hypertension (%) | 64 (80) | 29 (74.4) | 35 (92.1) | 0.06* |
Baseline sCr (mg/dL) (IQR) | 2.9 (2.3) | 3.1 (2.5) | 2.8 (1.9) | 0.58 |
CKD (%) | 34 (44.2) | 16 (41) | 18 (47.4) | 0.57 |
Baseline GFR (ml/min/1.73m2) (IQR) | 28 (21) | 31 (22) | 28 (46) | 0.98 |
Acute myocardial infraction (%) | 16 (21.3) | 8 (21.1) | 8 (21.6) | 0.95 |
Chronic heart failure (%) | 50 (65.8) | 26 (66.7) | 24 (64.9) | 0.86 |
Hypothyroidism (%) | 8 (10.7) | 6 (16.2) | 2 (5.3) | 0.15* |
Arrythmia (%) | 11 (14.3) | 5 (12.8) | 6 (15.8) | 0.75* |
Current smoker (%) | 36 (46.8) | 16 (41) | 20 (52.6) | 0.31 |
Vital signs and baseline laboratory results | ||||
Heart rate (bpm) (IQR) | 85 (26) | 87 (19) | 82 (24) | 0.32 |
Oxygen saturation (%) (IQR) | 94 (4) | 95 (4) | 94 (4) | 0.63 |
Systolic blood pressure (mmHg) (SD) | 130 ± 23 | 126 ± 23 | 134 ± 22 | 0.11 |
Diastolic blood pressure (mmHg) (SD) | 75 ± 13 | 74 ± 12 | 77 ± 14 | 0.23 |
Uric acid (mg/dL) (IQR) | 8.6 (2.2) | 8.5 (1.4) | 9.1 (3.3) | 0.34 |
Proteinuria, dipstick (%) | 38 (64.4) | 20 (66.7) | 18 (62.1) | 0.71 |
Hematuria (%) | 34 (57.6) | 19 (63.3) | 15 (51.7) | 0.37 |
BNP (ng/dL) (SD) | 2631 ± 1713 | 2501 ± 1669 | 2718 ± 1836 | 0.81 |
Copeptin (ng/dL) (IQR) | 75 (121) | 75 (178) | 72 (66) | 0.60 |
Management | ||||
Antibiotics (%) | 49 (65.3) | 23 (60.5) | 26 (70.3) | 0.37 |
Blood Transfusion (%) | 4 (5.4) | 3 (8.1) | 1 (2.7) | 0.61* |
Vasopressor (%) | 5 (6.8) | 3 (8.1) | 2 (5.4) | 0.67* |
Inotropic (%) | 2 (2.7) | 1 (2.7) | 1 (2.7) | 1.0* |
Diuretics (%) | 16 (20) | 10 (25) | 6 (15) | 0.26 |
Urinary volume (ml/ day) (IQR) | 1266.57 (675) | 1278.93 (675) | 1235.38 (638) | 0.56* |
Saline 0,9% IV fluid (%) | 4 (5) | 2 (5) | 2 (5) | 1.0* |
Hartmann IV fluid (%) | 56 (70.9) | 27 (67.5) | 29 (74.4) | 0.50 |
Department of admission | ||||
Internal medicine (%) | 47 (60.3) | 24 (61.5) | 23 (59) | 0.81 |
Cardiology (%) | 28 (35.9) | 14 (35.9) | 14 (35.9) | 1.0 |
Intensive care unit (%) | 1 (1.3) | 0 | 1 (2.6) | 0.49* |
Surgical specialty (%) | 2 (2.6) | 1 (2.6) | 1 (2.6) | 1.0 |