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Table 1 Demographic and clinical characteristics of 80 CRS1 patients according to allocation group

From: The Effect in Renal Function and Vascular Decongestion in Type 1 Cardiorenal Syndrome Treated with Two Strategies of Diuretics, a Pilot Randomized Trial

  All patients n = 80 Stepped Furosemide n = 40 Combined Diuretics n = 40 p
Male (%) 37 (46.2) 19 (47.5) 18 (45) 0.82
Age (years) 59 ± 14.5 58 ± 14.5 59 ± 14.6 0.73
Comorbidities     
Diabetes (%) 55 (71.4) 25 (64.1) 30 (78.9) 0.15
Hypertension (%) 64 (80) 29 (74.4) 35 (92.1) 0.06*
Baseline sCr (mg/dL) (IQR) 2.9 (2.3) 3.1 (2.5) 2.8 (1.9) 0.58
CKD (%) 34 (44.2) 16 (41) 18 (47.4) 0.57
Baseline GFR (ml/min/1.73m2) (IQR) 28 (21) 31 (22) 28 (46) 0.98
Acute myocardial infraction (%) 16 (21.3) 8 (21.1) 8 (21.6) 0.95
Chronic heart failure (%) 50 (65.8) 26 (66.7) 24 (64.9) 0.86
Hypothyroidism (%) 8 (10.7) 6 (16.2) 2 (5.3) 0.15*
Arrythmia (%) 11 (14.3) 5 (12.8) 6 (15.8) 0.75*
Current smoker (%) 36 (46.8) 16 (41) 20 (52.6) 0.31
Vital signs and baseline laboratory results     
Heart rate (bpm) (IQR) 85 (26) 87 (19) 82 (24) 0.32
Oxygen saturation (%) (IQR) 94 (4) 95 (4) 94 (4) 0.63
Systolic blood pressure (mmHg) (SD) 130 ± 23 126 ± 23 134 ± 22 0.11
Diastolic blood pressure (mmHg) (SD) 75 ± 13 74 ± 12 77 ± 14 0.23
Uric acid (mg/dL) (IQR) 8.6 (2.2) 8.5 (1.4) 9.1 (3.3) 0.34
Proteinuria, dipstick (%) 38 (64.4) 20 (66.7) 18 (62.1) 0.71
Hematuria (%) 34 (57.6) 19 (63.3) 15 (51.7) 0.37
BNP (ng/dL) (SD) 2631 ± 1713 2501 ± 1669 2718 ± 1836 0.81
Copeptin (ng/dL) (IQR) 75 (121) 75 (178) 72 (66) 0.60
Management     
Antibiotics (%) 49 (65.3) 23 (60.5) 26 (70.3) 0.37
Blood Transfusion (%) 4 (5.4) 3 (8.1) 1 (2.7) 0.61*
Vasopressor (%) 5 (6.8) 3 (8.1) 2 (5.4) 0.67*
Inotropic (%) 2 (2.7) 1 (2.7) 1 (2.7) 1.0*
Diuretics (%) 16 (20) 10 (25) 6 (15) 0.26
Urinary volume (ml/ day) (IQR) 1266.57 (675) 1278.93 (675) 1235.38 (638) 0.56*
Saline 0,9% IV fluid (%) 4 (5) 2 (5) 2 (5) 1.0*
Hartmann IV fluid (%) 56 (70.9) 27 (67.5) 29 (74.4) 0.50
Department of admission     
Internal medicine (%) 47 (60.3) 24 (61.5) 23 (59) 0.81
Cardiology (%) 28 (35.9) 14 (35.9) 14 (35.9) 1.0
Intensive care unit (%) 1 (1.3) 0 1 (2.6) 0.49*
Surgical specialty (%) 2 (2.6) 1 (2.6) 1 (2.6) 1.0
  1. IV, intravenous; CKD, chronic kidney disease; sCr, serum creatinine; GFR, glomerular filtration rate; SD, standard deviation; IQR, interquartile range. *Fisher’s exact test was used