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Table 3 Adjusted Odds Ratios of Developing AKI by Different Definitions/Populations

From: SARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution

Age Bracket Original Full-Age Spectrum Modified MDRD No Pre-Existing Comorbidities
10–15-year-olds 2.74 (1.66–4.56)* 2.49 (1.47–4.22)** 2.66 (1.60–4.41)** 5.35 (2.42–11.81)*
40–45-year-olds 1.39 (0.97–2.00) 1.34 (1.00–1.80)*** 1.48 (1.03–2.11)*** 1.24 (0.65–2.37)
70–75-year-olds 2.31 (1.71–3.12)* 2.79 (2.09–3.94)* 2.48 (1.87–3.29)* 2.34 (1.13–4.84)***
  1. Table presents snapshot of odds ratios (95% confidence intervals) for developing acute kidney injury (AKI) compared to 30–35-year-olds. Odds ratios adjusted for sex, race/ethnicity, hypertension, diabetes mellitus, cancer, chronic kidney disease, and severity of illness. Original column defines AKI per KDIGO guidelines when making assumptions about estimating a baseline creatinine. Full-age spectrum column defines AKI per KDIGO guidelines but assumes a more gradual change in eGFR across the age spectrum and uses the previously validated full age spectrum equation to estimate a baseline creatinine. Modified MDRD column defines AKI per KDIGO guidelines when making assumptions about estimating a baseline creatinine, but for adult patients does not include race as a variable in the MDRD equation. The final column only includes hospitalized patients with no pre-existing comorbidities, as such its adjustment model is limited to sex, race/ethnicity, and severity of illness
  2. * p < 0.0001
  3. **p < 0.001
  4. ***p ≤ 0.05