|
Age Bracket
|
Original
|
Full-Age Spectrum
|
Modified MDRD
|
No Pre-Existing Comorbidities
|
|---|
|
10–15-year-olds
|
2.74 (1.66–4.56)*
|
2.49 (1.47–4.22)**
|
2.66 (1.60–4.41)**
|
5.35 (2.42–11.81)*
|
|
40–45-year-olds
|
1.39 (0.97–2.00)
|
1.34 (1.00–1.80)***
|
1.48 (1.03–2.11)***
|
1.24 (0.65–2.37)
|
|
70–75-year-olds
|
2.31 (1.71–3.12)*
|
2.79 (2.09–3.94)*
|
2.48 (1.87–3.29)*
|
2.34 (1.13–4.84)***
|
- Table presents snapshot of odds ratios (95% confidence intervals) for developing acute kidney injury (AKI) compared to 30–35-year-olds. Odds ratios adjusted for sex, race/ethnicity, hypertension, diabetes mellitus, cancer, chronic kidney disease, and severity of illness. Original column defines AKI per KDIGO guidelines when making assumptions about estimating a baseline creatinine. Full-age spectrum column defines AKI per KDIGO guidelines but assumes a more gradual change in eGFR across the age spectrum and uses the previously validated full age spectrum equation to estimate a baseline creatinine. Modified MDRD column defines AKI per KDIGO guidelines when making assumptions about estimating a baseline creatinine, but for adult patients does not include race as a variable in the MDRD equation. The final column only includes hospitalized patients with no pre-existing comorbidities, as such its adjustment model is limited to sex, race/ethnicity, and severity of illness
- * p < 0.0001
- **p < 0.001
- ***p ≤ 0.05
