Fig. 1

Participant Flow for Women Subgroup. In the parent study, 5 patients discontinued treatment in the veverimer group (1 dialysis, 1 adverse event, 3 withdrawal or discontinuation for other reasons) and 4 patients discontinued treatment in the placebo group (2 died, 1 adverse event, and 1 withdrawal) before week 12. Five patients in the veverimer group and 6 patients in the placebo group declined to participate in the extension study, and one patient in the placebo group was ineligible for participation in the extension study. In the overall extension study, 3 patients discontinued treatment in the veverimer group (1 withdrawal and 2 lost to follow-up) and 8 patients discontinued treatment in the placebo group (2 died, 1 dialysis, 3 withdrawals, 1 lost to follow-up, and 1 other)