Table 1 Baseline demographic and clinical characteristics
Parameter | Overall Population | Subgroup of Women | ||
|---|---|---|---|---|
Veverimer (N = 114) | Placebo (N = 82) | Veverimer (N = 46) | Placebo (N = 31) | |
Age (y), mean (SD) | 62.9 (12.1) | 61.7 (11.9) | 65.7 (10.5) | 65.0 (7.2) |
Age ≥ 65 years | 58 (51) | 38 (62) | 25 (54) | 17 (55) |
Sex (female), n (%) | 46 (40) | 31 (38) | 46 (100) | 31 (100) |
Race (White), n (%) | 113 (99) | 79 (96) | 45 (98) | 30 (97) |
Body mass index (kg/m2) | 28.7 (4.0) | 27.9 (3.9) | 28.5 (3.5) | 27.8 (3.2) |
SBP (mmHg), mean (SD) | 135.9 (8.9) | 136.5 (9.0) | 133.4 (7.1) | 134.9 (7.4) |
Selected medical history, n (%) | ||||
Hypertension | 110 (96) | 79 (96) | 44 (96) | 29 (94) |
Congestive heart failure | 34 (30) | 28 (34) | 10 (22) | 13 (42) |
Left ventricular hypertrophy | 56 (49) | 35 (43) | 19 (41) | 14 (45) |
Diabetes | 70 (61) | 57 (70) | 27 (59) | 22 (71) |
Myocardial infarction | 17 (15) | 10 (12) | 5 (11) | 2 (7) |
Percutaneous coronary intervention or coronary bypass graft | 19 (17) | 14 (17) | 5 (11) | 3 (10) |
Peripheral vascular disease | 5 (4) | 6 (7) | 1 (2) | 2 (7) |
Stroke | 8 (7) | 8 (10) | 3 (7) | 3 (10) |
Laboratory values, mean (SD) | ||||
Serum bicarbonate (mmol/L) | 17.2 (1.4) | 17.1 (1.5) | 17.2 (1.5) | 17.3 (1.3) |
eGFR (mL/min/1.73 m2) | 29.4 (6.4) | 27.9 (5.4) | 28.5 (5.6) | 28.2 (4.9) |
Serum potassium (mmol/L) | 4.9 (0.6) | 4.9 (0.6) | 4.9 (0.7) | 4.7 (0.4) |
Hemoglobin A1c (%) | 6.1 (0.9) | 6.2 (1.1) | 6.0 (1.2) | 6.2 (1.2) |
Serum albumin (g/dL) | 4.1 (0.4) | 4.0 (0.3) | 4.1 (0.4) | 4.1 (0.3) |
ACR (mg/g), geometric mean (95% CI) | 209 (147, 297) | 305 (207, 449) | 127 (71, 229) | 204 (111, 376) |
ACR > 300 mg/g, n (%) | 50 (47) | 49 (65) | 16 (36) | 11 (36) |
Hemoglobin (g/dL), mean (SD) | 12.6 (1.8) | 12.6 (1.7) | 12.1 (1.4) | 12.2 (1.7) |
Concomitant medications, n (%) | ||||
ACE inhibitor or ARB | 75 (67) | 66 (82) | 29 (63) | 23 (74) |
Sodium bicarbonate | 11 (10) | 5 (6) | 3 (10) | 4 (9) |
Physical functioning, mean (SD) | ||||
KDQOL-PFD total score | 52.6 (22.4) | 55.7 (26.2) | 48.4 (21.9 | 58.2 (22.3) |
Repeated chair stand (s) | 21.7 (16.9) | 21.0 (17.1) | 21.7 (18.6) | 21.5 (17.2) |