Table 4 Definition of composite clinical endpoints

1.A doubling of serum creatinine levels

Doubling of the serum creatinine level from baseline sustained for at least 30 days according to central laboratory assessment

2.End-stage kidney disease (ESKD)

eGFR < 15 ml/min for CKD 1–4 patients; or dialysis or kidney transplant for CKD 1–5 patients

3.Loss of renal function

 ≥ 40% decline in GFR from baseline

4.Death

Death from any cause

5.Major cardiovascular or cerebrovascular events

Acute heart failure, myocardial infarction, ischemic cerebral infarction or intracranial hemorrhage