Parameters | Low-sodium+placebo (n = 27) | Medium-sodium+SPL (n = 24) | Low-sodium+SPL (n = 23) | P |
---|---|---|---|---|
Male, N (%) | 14 (52%) | 9 (38%) | 16 (70%) | 0.763 |
Age (years) | 42.44 ± 11.52 | 39.71 ± 9.68 | 43.00 ± 12.65 | 0.563 |
CKD stages, N (%) | Â | Â | Â | 0.967 |
 Stage 1 | 16 (59%) | 15 (62%) | 13 (57%) |  |
 Stage 2 | 7 (26%) | 5 (21%) | 7 (30%) |  |
 Stage 3a | 4 (15%) | 4 (17%) | 3 (13%) |  |
Renal diagnosis, N (%) | Â | Â | Â | 0.791 |
 IgA nephropathy | 13 (48%) | 14 (58%) | 13 (57%) |  |
 MsPGN | 0 | 1 (4%) | 1 (4%) |  |
 MN | 0 | 1 (4%) | 1 (4%) |  |
 MCD | 1 (4%) | 0 | 0 |  |
 No renal biopsy | 13 (48%) | 8 (33%) | 8 (35%) |  |
Antihypertensive drugs, N (%) | ||||
 ARB | 20 (74%) | 19 (79%) | 20 (87%) | 0.548 |
 CCB | 3 (11%) | 2 (8%) | 3 (13%) | 0.901 |
 β-blocker | 0 | 1 | 0 |  |
BMI (kg/m2) | 24.16 ± 3.42 | 23.50 ± 3.60 | 23.45 ± 3.65 | 0.728 |
TC (mmol/L) | 4.57 ± 0.86 | 4.56 ± 1.07 | 4.54 ± 0.77 | 0.993 |
TG (mmol/L) | 1.38 ± 0.62 | 2.30 ± 2.06 | 1.75 ± 0.90 | 0.053 |
LDL-C (mmol/L) | 2.57 ± 0.56 | 2.83 ± 0.78 | 2.76 ± 0.70 | 0.364 |
SBP (mmHg) | 118.15 ± 9.81 | 119.29 ± 11.51 | 122.30 ± 11.85 | 0.403 |
DBP (mmHg) | 72.30 ± 7.31 | 72.88 ± 9.13 | 72.87 ± 10.46 | 0.965 |
Blood potassium (mmol/L) | 4.34 ± 0.39 | 4.22 ± 0.39 | 4.23 ± 0.40 | 0.476 |
UNa (mmol/d) | 138.48 ± 60.92 | 157.70 ± 70.00 | 154.68 ± 87.55 | 0.598 |
UK (mmol/d) | 54.29 ± 17.61 | 51.25 ± 13.57 | 51.31 ± 11.32 | 0.700 |
24-h urine protein (g/d) | 0.37 (0.23, 0.67) | 0.41 (0.32, 0.64) | 0.35 (0.28, 0.56) | 0.482 |
24-h urine creatinine (mmol/d) | 10.91 (9.03,13.03) | 9.41 (7.13,11.91) | 11.20 (8.99,13.14) | 0.128 |
24-h urine protein to creatinine ratio (g/mol) | 30.22 (19.00,69.46) | 50.88 (27.91,73.03) | 34.89 (26.60,52.94) | 0.342 |
eGFR (ml/min/1.73m2) | 93.15 ± 30.94 | 98.18 ± 30.75 | 94.48 ± 27.11 | 0.826 |
Scr (μmol/L) | 81.66 ± 28.61 | 76.42 ± 30.90 | 83.43 ± 28.73 | 0.694 |
BUN (mmol/L) | 6.02 ± 1.62 | 5.66 ± 1.82 | 5.78 ± 2.03 | 0.767 |
Alb (g/L) | 43.66 ± 2.26 | 42.78 ± 2.71 | 42.77 ± 2.64 | 0.356 |
PA (g/L) | 0.33 ± 0.07 | 0.34 ± 0.06 | 0.35 ± 0.09 | 0.622 |
UA (μmol/L) | 374.90 ± 75.84 | 360.29 ± 83.86 | 378.09 ± 75.51 | 0.705 |
CRP (mg/L) | 1.76 ± 1.98 | 1.26 ± 1.01 | 1.51 ± 1.56 | 0.547 |
eDPI (g/kg/d) | 1.06 ± 0.21 | 1.00 ± 0.26 | 1.08 ± 0.23 | 0.465 |