Table 3 Clinical parameters before and after intervention (PP set)
Parameters | Low-sodium+placebo (n = 27) | Medium-sodium+SPL (n = 24) | Low-sodium+SPL (n = 23) | P among groups | |
|---|---|---|---|---|---|
Primary endpoint 24-h urine protein (g/d) | Before intervention | 0.37 (0.23,0.67) | 0.41 (0.32,0.64) | 0.35 (0.28,0.56) | 0.482 |
At 12 weeks | 0.21 (0.16,0.50) | 0.27 (0.15,0.41) | 0.30 (0.17,0.60) | 0.827 | |
Change between pre- and post- intervention | −0.06 (−0.24,0) | −0.17 (−0.25,-0.01) | −0.12 (− 0.27,0.05) | 0.721 | |
P within the group | 0.004 | 0.009 | 0.021 | Â | |
24 h urine protein to creatinine ratio (g/mol) | Before intervention | 30.22 (19.00,69.46) | 50.88 (27.91,73.03) | 34.89 (26.60,52.94) | 0.342 |
|  | At 12 weeks | 24.62 (14.02,48.32) | 23.77 (17.36,40.31) | 30.00 (15.49,56.97) | 0.957 |
|  | Change between pre- and post- intervention | −3.72 (−16.42,1.04) | −15.85 (−41.40,-3.27) | −11.70 (−22.88,10.92) | 0.112 |
| Â | P within the group | 0.030 | 0.012 | 0.046 | Â |
Secondary endpoint eGFR (ml/min/1.73m2) | Before intervention | 93.15 ± 30.94 | 98.18 ± 30.75 | 94.48 ± 27.11 | 0.826 |
12 weeks | 96.56 ± 31.20 | 93.50 ± 25.36 | 94.35 ± 28.99 | 0.925 | |
Change between pre- and post-intervention [95% confidence interval] | 3.41 [−0.57,7.39] | −4.68 [−12.10,2.74] | −0.13 [−3.90,3.64] | 0.082 | |
P within the group | 0.090 | 0.205 | 0.944 | Â | |