Fig. 6

Simplified graphical presented associations between sepsis, nephrotoxic antibiotics, investigated miRNAs and their target regulatory genes in sepsis induced acute kidney injury. On the figure are presented simplified associations between gentamicin, vancomycin, endotoxin, ischemia/reperfusion injury and miR-15a-5p, miR-423-5p, miR-192-5p and miR-155-5p with their previously established target genes. Acute kidney injury in sepsis is a complex process involving combination of risk factors as ischemia, inflammation and possible nephrotoxicity. Abbreviations: AKI – acute kidney injury, Bax – B-cell lymphoma 2 Asociated X, Apoptosis Regulator, DDIT4 – DNA damage–inducible transcript 4, FOXA1 – forkhead box protein A1, GSTM1 – glutathione-S-transferase M1, IFR2BP2-NFAT1 – interferon regulatory factor 2 binding protein 2–nuclear factor of activated T cells 1, MAFF – MAF basic leucine zipper transcription factor F, miR – micro RNA, MYLK – myosin light chain kinase, PRG2 – proteoglycan 2, pro eosinophil, major basic protein, p21– p21 gene, p53 – p53 gene, TNIP2 –TNFAIP3 interacting protein 2 gene, VEGFA – vascular endothelial growth factor A gene, VEGFC – vascular endothelial growth factor C gene, XIAP – X-linked inhibitor of apoptosis, XIST-CUL3 – X inactive specific transcript - cullin 3 gene