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Table 7 Concentrations of miRNAs in patients with and without acute kidney injury on day 7

From: Expression and 7-day time course of circulating microRNAs in septic patients treated with nephrotoxic antibiotic agents

Group

miRNA

No AKI

AKI

 
  

Median

IQR

Median

IQR

P

Vancomycin

hsa-miR-15a-5p (amol/L)

132.7

105.9–228.2

228.4

144.9–368.3

0.229

hsa-miR-155-5p (amol/L)

4.3

3.7–4.7

7.4

3.5–26.6

0.400

hsa-miR-192-5p (amol/L)

21.4

10.4–68.6

96.8

69.9–101.8

0.114

hsa-miR-423-5p (amol/L)

640.4

407.5–895.0

1004.0

768.5–3313.0

0.229

Gentamicin

hsa-miR-15a-5p (amol/L)

274.7

125.5–467.0

109.6

75.1–182.6

0.013

hsa-miR-155-5p (amol/L)

4.5

3.0–5.8

5.5

4.2–6.5

0.182

hsa-miR-192-5p (amol/L)

33.4

25.1–62.7

30.4

10.9–63.9

0.824

hsa-miR-423-5p (amol/L)

1024.0

517.2–1156.0

1016.0

634.9–1651

0.552

oATB

hsa-miR-15a-5p (amol/L)

171.2

137.4–292.0

277.8

222.0–432.6

0.299

hsa-miR-155-5p (amol/L)

4.9

3.7–6.9

6.9

4.4–10.0

0.270

hsa-miR-192-5p (amol/L)

32.8

26.4–85.3

81.9

34.6–125.6

0.227

hsa-miR-423-5p (amol/L)

668.7

513.3–973.1

812.0

493.3–2358.0

0.592

  1. Abbreviations: AKI acute kidney injury, IQR interquartile range, miRNA microRNA; p values per Mann–Whitney U test