Fig. 2

PPS inhibited the PI3K/AKT signaling in AGEs-treated SV40 MES13 cells. A Top 20 enriched KEGG pathways of the putative target genes of the differentially expressed miRNAs induced by PPS co-treatment in AGEs-treated SV40 RES13 cells. B Representative western blots of p-PI3K, PI3K, p-AKT, and AKT in SV40 RES13 cells treated with AGEs in the presence or absence of PPS for 24 h, as well as statistical analyses of western blots. C Network map of miRNA-mRNA interactions of the differentially expressed miRNAs involved in the PI3K/AKT pathway. Red square frame highlights mmu-miR-466a-3p