Sham + ND + PBO (n = 12–13) | 5/6Nx + ND + PBO (n = 12–13) | 5/6Nx + HSD + PBO (n = 15–23) | 5/6Nx + HSD + TELM (n = 11–15) | 5/6Nx + HSD + LINA (n = 13–15) | 5/6Nx + HSD + EMPA (n = 10–11) | |
---|---|---|---|---|---|---|
Final body weight (g) | 475.35 ± 12.04 | 448.50 ± 17.38 | 443.35 ± 10.65 | 394.65 ± 12.51ab | 382.39 ± 12.44ab | 420.03 ± 11.68a |
Relative left kidney weight (mg/g) | 3.20(2.93–3.46)b | 3.44(2.93–3.46) | 3.64(3.31–4.35)a | 3.56(3.15–4.26) | 3.72(3.41–4.13)a | 3.94(3.49–4.46)a |
Relative heart weight (mg/g) | 2.74 ± 0.06b | 3.03 ± 0.08 | 3.74 ± 0.21a | 3.97 ± 0.33a | 3.77 ± 0.23a | 3.58 ± 0.13a |
Relative liver weight (mg/g) | 24.03(23.27–25.62) | 24.25(23.27–25.62) | 26.46(22.36–27.54) | 21.94(21.24–24.01) | 22.88(21.80–24.56) | 21.70(20.99–22.58)ab |
Final systolic blood pressure (mm Hg) | 124.66(118.33–130.50)b | 153.66(118.33–130.50)a | 153.00(149.00–163.66)a | 127.33(118.00–129.66)b | 133.83(129.75–142.25)b | 126.33(124.66–131.00) |
Final diastolic blood pressure (mm Hg) | 101.56 ± 2.43b | 122.77 ± 3.68a | 123.61 ± 2,21a | 99.36 ± 2.47b | 116.52 ± 3.01a | 98.63 ± 2.56b |
Final plasma creatinine (μmol/l) | 46.92 ± 0.76b | 72.38 ± 2.27 | 84.78 ± 7.61a | 102.80 ± 12.04a | 95.71 ± 6.38a | 88.80 ± 4.64a |
Final plasma urea (mmol/l) | 4.89 ± 0.21 | 11.18 ± 1.08 | 12.66 ± 3.46 | 16.94 ± 1.86a | 15.84 ± 2.22a | 14.87 ± 0.72 |
Final plasma glucose (mmol) | 6.08(5.62–7.18) | 9.03(5.62–7.18)# | 6.52(5.36–7.69) | 6.25(5.14–6.85) | 7.16(6.20–8.51) | 6.31(5.42–6.59) |
Final plasma insulin (μg/l) | 0.72(0.38–1.37) | 0.53(0.38–1.37) | 0.30(0.22–0.83) | 0.20(0.10–0.33)a | 0.19(0.13–0.51)a | 0.18(0.09–0.32)a |
Final plasma BNP45 (ng/ml) | 2.23 ± 0.49 | 1.92 ± 0.30 | 2.13 ± 0.32 | 2.11 ± 0.32 | 2.15 ± 0.31 | 1.91 ± 0.41 |
GFR/BW (ml/24 h/g) | 1.97(1.23–3.15) | 1.62(1.23–3.15) | 1.99(1.47–2.11) | 1.47(1.22–1.72) | 1.41(1.31–1.73) | 1.74(1.34–2.15) |
Final urinary creatinine (mmol/l) | 11.41(6.39–15.23) | 6.49(6.39–15.23) | 6.74(4.64–8.69) | 5.34(3.84–6.05)a | 5.53(4.67–6.89)a | 5.42(4.89–8.03) |
Final urinary ACR (mg/mmol) | 1.51(1.27–2.27)b | 6.89(5.51–15.82)ab | 38.49(11.10–282.90)a | 44.10(2.57–249.2)a | 92.80(20.31–219.70)a | 34.87(9.45–230.80)a |
Final 24 h urinary protein excretion (mg/24 h) | 4.81(4.23–5.79)b | 7.17(6.35–10.47)b | 11.63(7.48–36.08)a | 19.97(5.04–28.9)a | 12.38(5.51–21.84)a | 10.56(7.35–21.92)a |