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Table 1 Clinical/Biochemical parameters

From: Regulation of SARS CoV-2 host factors in the kidney and heart in rats with 5/6 nephrectomy—effects of salt, ARB, DPP4 inhibitor and SGLT2 blocker

 

Sham + ND + PBO (n = 12–13)

5/6Nx + ND + PBO (n = 12–13)

5/6Nx + HSD + PBO (n = 15–23)

5/6Nx + HSD + TELM (n = 11–15)

5/6Nx + HSD + LINA (n = 13–15)

5/6Nx + HSD + EMPA (n = 10–11)

Final body weight (g)

475.35 ± 12.04

448.50 ± 17.38

443.35 ± 10.65

394.65 ± 12.51ab

382.39 ± 12.44ab

420.03 ± 11.68a

Relative left kidney weight (mg/g)

3.20(2.93–3.46)b

3.44(2.93–3.46)

3.64(3.31–4.35)a

3.56(3.15–4.26)

3.72(3.41–4.13)a

3.94(3.49–4.46)a

Relative heart weight (mg/g)

2.74 ± 0.06b

3.03 ± 0.08

3.74 ± 0.21a

3.97 ± 0.33a

3.77 ± 0.23a

3.58 ± 0.13a

Relative liver weight (mg/g)

24.03(23.27–25.62)

24.25(23.27–25.62)

26.46(22.36–27.54)

21.94(21.24–24.01)

22.88(21.80–24.56)

21.70(20.99–22.58)ab

Final systolic blood pressure (mm Hg)

124.66(118.33–130.50)b

153.66(118.33–130.50)a

153.00(149.00–163.66)a

127.33(118.00–129.66)b

133.83(129.75–142.25)b

126.33(124.66–131.00)

Final diastolic blood pressure (mm Hg)

101.56 ± 2.43b

122.77 ± 3.68a

123.61 ± 2,21a

99.36 ± 2.47b

116.52 ± 3.01a

98.63 ± 2.56b

Final plasma creatinine (μmol/l)

46.92 ± 0.76b

72.38 ± 2.27

84.78 ± 7.61a

102.80 ± 12.04a

95.71 ± 6.38a

88.80 ± 4.64a

Final plasma urea (mmol/l)

4.89 ± 0.21

11.18 ± 1.08

12.66 ± 3.46

16.94 ± 1.86a

15.84 ± 2.22a

14.87 ± 0.72

Final plasma glucose (mmol)

6.08(5.62–7.18)

9.03(5.62–7.18)#

6.52(5.36–7.69)

6.25(5.14–6.85)

7.16(6.20–8.51)

6.31(5.42–6.59)

Final plasma insulin (μg/l)

0.72(0.38–1.37)

0.53(0.38–1.37)

0.30(0.22–0.83)

0.20(0.10–0.33)a

0.19(0.13–0.51)a

0.18(0.09–0.32)a

Final plasma BNP45 (ng/ml)

2.23 ± 0.49

1.92 ± 0.30

2.13 ± 0.32

2.11 ± 0.32

2.15 ± 0.31

1.91 ± 0.41

GFR/BW (ml/24 h/g)

1.97(1.23–3.15)

1.62(1.23–3.15)

1.99(1.47–2.11)

1.47(1.22–1.72)

1.41(1.31–1.73)

1.74(1.34–2.15)

Final urinary creatinine (mmol/l)

11.41(6.39–15.23)

6.49(6.39–15.23)

6.74(4.64–8.69)

5.34(3.84–6.05)a

5.53(4.67–6.89)a

5.42(4.89–8.03)

Final urinary ACR (mg/mmol)

1.51(1.27–2.27)b

6.89(5.51–15.82)ab

38.49(11.10–282.90)a

44.10(2.57–249.2)a

92.80(20.31–219.70)a

34.87(9.45–230.80)a

Final 24 h urinary protein excretion (mg/24 h)

4.81(4.23–5.79)b

7.17(6.35–10.47)b

11.63(7.48–36.08)a

19.97(5.04–28.9)a

12.38(5.51–21.84)a

10.56(7.35–21.92)a

  1. GFR/BW (ml/24 h/g) = [urinary creatinine * urinary flow (ml/min)]/[serum creatinine * body weight]
  2. Urinary ACR (mg/mmol) = urinary albuminuria / urinary creatinine
  3. Normally distributed data were given as mean ± SEM. Non-normally distributed data were given as median (25th–75th percentile)
  4. #ap < 0.05 vs. Sham + ND + PBO, *bp < 0.05 vs. 5/6Nx + HSD + PBO