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Table 2 Study outcomes of survivors of critical illness at 3 months following hospital discharge according to AKI status during index ICU admission

From: Acute kidney injury contributes to worse physical and quality of life outcomes in survivors of critical illness

Parameter

No AKI/AKI stage 1

n = 59

AKI stage 2 or 3

n = 45

P-value

Attrition

Physical function assessment

 6 MWD, meters, mean ± SD (n)

295 ± 153 (38)

223 ± 132 (25)

p = 0.059

39%

 6 MWD achieved from predicted, %,median [IQR] (n)

58 [34 – 78] (38)

38 [29 – 56] (25)

p = 0.041

39%

 Chair Stand Test, sec, median [IQR]

10 [8-13] (38)

12 [10 – 15] (29)

p = 0.197

35%

 4-m gait speed, m/sec, mean ± SD (n)

0.91 ± 0.3 (38)

0.71 ± 0.22 (29)

p = 0.009

35%

 SPPB, 0-12, median [IQR] (n)

11 [7 – 12] (38)

8 [5 – 11] (29)

p = 0.056

35%

 MRC-ss, 0-60, median [IQR] (n)

58 [54 – 60] (38)

54 [48 – 58] (29)

p = 0.009

35%

HRQOL assessment

 EQ-5D VAS, 0-100, mean ± SD (n)

77.9 ± 14.2 (54)

69.2 ± 20.9 (38)

p = 0.019

12%

 Return to work/hobby, yes, % (n)

50% (29/58)

22% (10/45)

p = 0.003

0%

 Return to driving, yes, % (n)

70% (39/56)

46% (19/41)

p = 0.016

0%

Cognitive function assessment

 MOCA, 0-30, median (IQR)

24.8 ± 3.7 (48)

24.8 ± 3.8 (37)

p = 0.861

18%

Emotional function assessment

 Anxiety (HADS), 0-21, median [IQR]

6 [2 – 11] (52)

7 [3 – 12] (41)

p = 0.270

10%

 Depression (HADS), 0-21, mean ± SD (n)

5.3 ± 4.0 (52)

7.0 ± 5.8 (41)

p = 0.108

10%

 IESR-S, 0-88, mean ± SD (n)

24.7 ± 21.6 (52)

28.8 ± 24.5 (41)

p = 0.400

10%

Clinical assessment

 90-day hospitalization/ED visit, % (n)

19% (11/59)

29% (13/45)

p = 0.247

0%

  1. HADS hospital anxiety and depression scale, IES-R Impact of Events Scale-Revised, MOCA Montreal Cognitive Assessment, ED emergency department, EQ-5D Euro-Quality of Life- Five-Dimension, VAS visual analog scale, SPPB short physical performance battery, MRC-ss Medical research council-sum scale, 6 MWD six-minute walk distance