Acute kidney injury contributes to worse physical and quality of life outcomes in survivors of critical illness

BMC Nephrology

Table 3 Multivariable models examining selected outcomes according to AKI status during index ICU admission as the independent variable

Outcome	Model 1	Model 2		Model 3
6MWD (meters)^a
AKI stage 2-3 vs. ref	−35.9 (−73.3, 1.38)	p = 0.059	−21.0 (−62.4, 20.4)	p = 0.314	−27.8 (−68.9, 13.3)	p = 0.181
EQ-5D VAS (0-100)^a
AKI stage 2-3 vs. ref	−4.35 (−7.98, −0.72)	p = 0.020	−4.01 (−8.25, 0.22)	p = 0.063	−4.01 (−8.25, 0.22)	p = 0.063
Return to driving (yes/no)^b
AKI stage 2-3 vs. ref	0.38 (0.16, 0.87)	p = 0.427	0.65 (0.23, 1.87)	p = 0.427	0.71 (0.24, 2.10)	p = 0.541
Return to work or hobby (yes/no)^b
AKI stage 2-3 vs. ref	0.29 (0.12, 0.68)	p = 0.005	0.37 (0.13, 1.05)	p = 0.062	0.37 (0.13, 1.05)	p = 0.062

Reference (ref) for all models was no AKI or AKI stage 1
Model 1: univariable model
Model 2: adjusted by sex, SOFA score, and Charlson score
Model 3: adjusted by model 2 + candidate variables age, BMI, days of mechanical ventilation, receipt of NMB, receipt of vasopressor/inotrope, hospital LOS, receipt of ECMO according to multivariable p-value ≤0.05. Final models included the addition of receipt of NMB (model of 6MWD) and days of mechanical ventilation (model of return to driving)
^a Data are presented as beta coefficient and 95% confidence intervals
^b Data are presented as odds ratios and 95% confidence intervals

ISSN: 1471-2369