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Fig. 3 | BMC Nephrology

Fig. 3

From: METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy

Fig. 3

NSD2 suppresses HG-induced activation of SV40-MES-13 cells and the fibrosis activity. A Expression of NSD2 in SV40-MES-13 cells after HG induction determined by RT-qPCR; B Transfection efficacy of vector-NSD2 determined by RT-qPCR; C DNA replication ability of cells examined by EdU labeling; D-F, MFI of COL1A1 (D), Fibronectin (E) and E-cadherin (F) in cells examined by immunofluorescence staining. Data were expressed as the mean ± SD from three independent experiments. Differences were analyzed by the unpaired t test (B) or one-way ANOVA (A, C, D, E and F). *p < 0.05

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BMC Nephrology

ISSN: 1471-2369

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