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Fig. 6 | BMC Nephrology

Fig. 6

From: METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy

Fig. 6

METTL3 upregulates NSD2 to reduce HG-induced mesangial cell activation and interstitial fibrosis. A Transfection efficacy of sh-NSD2 in SV40-MES-13 cells after vector-METTL3 transfection determined by RT-qPCR; B DNA replication ability of cells examined by EdU labeling; C-E, MFI of COL1A1 (C), Fibronectin (D) and E-cadherin (E) in cells examined by immunofluorescence staining. Data were expressed as the mean ± SD from three independent experiments. Differences were analyzed by unpaired t test (A) or one-way (B-E). *p < 0.05

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BMC Nephrology

ISSN: 1471-2369

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