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Fig. 7 | BMC Nephrology

Fig. 7

From: METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy

Fig. 7

METTL3 upregulates NSD2 to alleviate interstitial fibrosis in the kidney tissues of mice with DN. A Kidney/body weight of mice; B Levels of FBG, SCr, S-Cys-C, 24-h U-protein, U-Cys-C, and SBP in mice; C Levels of SOD, MDA, IL-6, MCP-1, and hydroxyproline in mouse kidney tissues determined by ELISA kits; D Protein levels of METTL3, NSD2, and the interstitial fibrosis-related proteins COL1A1, Fibronectin and E-cadherin in mouse kidney tissues determined by western blot analysis; E Pathological changes in mouse kidney tissues determined by HE staining; F Collagen deposition in mouse kidney tissues determined by Masson’s trichrome staining. There were at least five mice in each group. Data were collected from three independent experiments and expressed as the mean ± SD. Differences were analyzed by two-way ANOVA (A, B, C, D and F). *p < 0.05

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