Fig. 3

Multivariable HRs for renal (A) and cardiovascular (B) outcomes over 1 year and after 5 years of follow-up in patients with anemia versus those without anemia at baseline. Baseline anemia was defined as Hb < 10 g/dL, determined from the lowest available Hb level within 6 months of the index date. Multivariable HRs were calculated using Cox proportional hazards models, simultaneously adjusted for baseline covariates sex, age strata [< 50; 50–59; 60–69; 70–79; and 80+ years], ethnicity, CKD stage, and anemia. Patients whose anemia status was unknown were excluded from analyses using these models. CI confidence interval, CKD chronic kidney disease, Hb hemoglobin, hHF hospitalization for heart failure, HR hazard ratio, hUA hospitalization for unstable angina, MACE major adverse cardiovascular event, MACE+ first occurrence of MACE outcome, hUA or hHF, MI myocardial infarction