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Table 2 Clinical course before and after SGLT-2 inhibitor administration

From: Empagliflozin in kidney transplant recipients with chronic kidney disease G3a-4 and metabolic syndrome: Five Japanese cases

 

Case 1

Case 2

Case 3

Case 4

Case 5

Body weight (Kg)

69.0/67.8

73.4/83.3

73.4/73.3

89.1/86.2

99.9/98.2

Waist circumference (cm)

92/90

104/106

91/89

94/91

112/111

SBP (mmHg)

159/103

140/124

132/131

135/125

126/139

SBP (mmHg)

79/60

72/66

76/78

79/77

85/87

Cr (mg/dL)

1.69/1.71

1.40/1.70

2.16/2.37

1.33/1.25

1.89/1.67

eGFR (ml/min/1.732)

32.8/32.1

39.5/33.9

25.9/23.4

45.0/47.9

32.4/36.0

UA(mg/dL)

5.1/5.4

4.2/4.0

4.4/3.9

5.5/5.8

4.1/5.5

ALT (IU/L)

9/8

73/51

16/9

26/21

39/36

γ-GTP (IU/L)

11/9

89/58

57/40

30/24

40/37

TG (mg/dL)

121/116

188/133

248/248

112/76

173/99

HbA1c (%)

6.8/6.4

6.0/5.9

5.5/5.6

7.6/7.1

6.0/5.8

UACR (mg/gCr)

135.7/27.7

35.8/10.8

790.0/650.0

24.0/19.1

46.9/23.6

Observation period

(months)

24

18

18

9

8

  1. Values show data before/after empagliflozin administration.
  2. Abbreviations: ALT alanine aminotransferase, Cr creatinine, γ-GTP γ-glutamyl transpeptidase, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, HbA1c hemoglobin A1c, SBP systolic blood pressure, TG triglyceride, UA uric acid, UACR urinary albumin-to-creatinine ratio