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Fig. 1 | BMC Nephrology

Fig. 1

From: Targeting inflammation for the treatment of Diabetic Kidney Disease: a five-compartment mechanistic model

Fig. 1

Histology showing the complex and heterogeneous glomerular pathology in DKD. A: Minimal to mild glomerular pathology with mild mesangial expansion; Tervaert class I–IIa [20]. B: Severe mesangial expansion and hypercellularity; Tervaert class IIb. C: Ischaemic phenotype with collapse of glomerular segments, segmental sclerosis and mild mesangial expansion; Tervaert class IIa. D: Severe mesangial expansion, Kimmelstiel-Wilson nodule without mesangiolysis; Tervaert class III. E: Hyperfiltrating phenotype with enlarged glomerular tuft, perihilar capsular adhesion and severe mesangial expansion; Tervaert class IIb. F: Mild mesangial expansion, Kimmelstiel-Wilson nodule with mesangiolysis; Tervaert class III

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