Strain | Model compartments (see Fig. 1) | Diabetogenic mechanism | Reported features |
---|---|---|---|
Type 1 diabetes | |||
 C57BL/6 | Immune cell recruitment, resorption, filtration | Streptozotocin | Mild glomerular and tubulointerstitial damage, mild albuminuria, GFR increase, hyperglycemia |
 Akita (Ins2C96Y) on C57BL/6 | Immune cell recruitment, structural support, filtration | Toxic mutation in insulin 2 gene | GBM thickening, mesangial expansion, albuminuria, hyperglycemia, hypertension |
 ApoE−/− on C57BL/6 | Immune cell recruitment, resorption, filtration | Streptozotocin + hyperlipidemia | Glomerular and tubulointerstitial damage, albuminuria, hyperglycemia |
 Nos3−/− on C57BL/6 | Immune cell recruitment, filtration | STZ + NO deficiency | Glomerular fibrosis, albuminuria, hyperglycemia |
 BALB/c | Immune cell recruitment, filtration | Streptozotocin | Glomerular damage, hyperglycemia; no change in GFR |
 DBA/2 J | Immune cell recruitment, resorption, structural support | Streptozotocin | Glomerular fibrosis, tubulointerstitial damage, hyperglycemia |
 Akita (Ins2C96Y) on DBA/2 J | Immune cell recruitment, resorption, filtration, structural support | Toxic mutation in insulin 2 gene | Albuminuria, hyperglycemia |
 OVE on FVB | Immune cell recruitment, resorption, filtration, structural support | Calmodulin mutation and toxic protein accumulation | Glomerular and tubulointerstitial fibrosis, albuminuria, GFR reduction, hyperglycemia, hypertension |
 TTRhRen on FVB | Immune cell recruitment, resorption, structural support | Hypertension + streptozotocin | Tubulointerstitial fibrosis, mesangial expansion, albuminuria, GFR decrease, hyperglycemia, hypertension |
 CD1 | Immune cell recruitment, resorption, structural support | Streptozotocin | Tubulointerstitial fibrosis, mesangial expansion, albuminuria, hyperglycemia |
 129/SV | Immune cell recruitment, filtration | Streptozotocin + 2 renin receptors | Albuminuria, hyperglycemia |
 Akita (Ins2C96Y) on 129/SV | Immune cell recruitment, structural support | Toxic mutation in insulin 2 gene | Mesangial expansion, albuminuria, hyperglycemia, hypertension |
 KKH1J | Immune cell recruitment, filtration | Streptozotocin | Glomerular damage, albuminuria, hyperglycemia |
 NOD Mice | Filtration, structural support | Genetic obesity + streptozotocin | Hyperglycemia |
Type 2 diabetes | |||
 Db/db on C57BL/Ks | Immune cell recruitment, structural support | Leptin resistance | Mesangial expansion, albuminuria, hyperglycemia |
 Db/db Nos3−/− on C57BL/Ks | Immune cell recruitment, filtration, and structural support | Leptin resistance + NO deficiency | Albuminuria, GFR decrease, hyperglycemia |
 Ob/ob | Immune cell recruitment, filtration, and structural support | Leptin deficiency | Hyperglycemia |
 Ob/ob on BTBR | Immune cell recruitment, filtration, and structural support | Leptin deficiency + hyperinsulinemia | Hyperglycemia |
 KK and KKay | Immune cell recruitment, filtration, and structural support | Agouti gene | Albuminuria, hyperglycemia, hypertension |