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Table 2 Correlation between serum leptin level group and other components

From: Serum leptin level and incidence of CKD: a longitudinal study of adult enrolled in the Korean genome and epidemiology study(KoGES)

  Serum leptin level
Tertile 1 Tertile 2 Tertile 3 P
All
N (%) 872 873 901  
Age, years 56.53 (8.09) 54.36 (8.28) 54.13 (7.98)  < 0.001
Hypertension, n (%) 137 (15.7) 168 (19.3) 245 (27.18)  < 0.001
Diabetes mellitus, n (%) 75 (8.6) 89 (10.18) 66 (7.36) 0.350
Dyslipidemia, n (%) 40 (4.53) 50 (5.73) 57 (6.34) 0.100
Myocardial infarction, n (%) 9 (1.05) 17 (1.99) 19 (2.15) 0.078
Cerebrovascular accident, n (%) 13 (1.51) 18 (2.11) 8 (0.91) 0.293
Current smoking (%) 334 (38.25) 110 (12.65) 19 (2.12)  < 0.005
Regular exercise (%) 211 (24.25) 254.48 (29.15) 254 (28.17) 0.067
Body mass index, kg/m2 23.07 (2.60) 24.33 92.69) 26.49 (3.08)  < 0.001
Waist circumference, cm 82.48 (7.74) 82.88 (9.21) 85.57 (8.52)  < 0.001
Systolic BP, mmHg 126.89 (17.05) 126.91 (17.59) 127.77 (18.00) 0.295
Diastolic BP, mmHg 83.23 (11.49) 82.89 (11.78) 82.87 (12.09) 0.530
Fasting glucose, mg/dL 95.96 (21.02) 96.47 (22.37) 93.49 (15.76) 0.008
HbA1c 5.56 (0.80) 5.64 (0.93) 5.62 (0.67) 0.218
HDL-cholesterol, mg/dL 47.14 (11.79) 45.98 (11.03) 47.60 (10.39) 0.365
LDL-cholesterol, mg/dL 111.15 (31.86) 117.22 (31.63) 127.37 (33.61)  < 0.001
Triglycerides, mg/dL 149.12 (114.04) 145.38 (95.17) 149.29 (83.00) 0.964
HOMA-IR, units 1.59 (1.16) 2.05 (2.14) 2.29 (1.25)  < 0.001
hs-CRP, mg/L 2.12 (6.09) 2.02 (4.29) 2.06 (4.26) 0.825
Baseline eGFR, mL/min/1.73m2 78.57 (10.21) 75.87 (9.91) 74.05 (9.04)  < 0.001
Follow-up eGFR, mL/min/1.73m2 82.71 (11.72) 80.18 (11.45) 77.73 (10.45)  < 0.001
Leptin, ng/L 1.82 (0.69) 4.96 (1.18) 12.29 (5.40)  < 0.001
Male
N (%) 362 363 375  
Age, years 57.20 (8.18) 55.79 (7.97) 55.62 (7.91) 0.008
Hypertension, n (%) 40 (11.08) 73 (20.11) 101 (26.83)  < 0.001
Diabetes mellitus, n (%) 15 (4.16) 48 (13.13) 56 (14.91)  < 0.001
Dyslipidemia, n (%) 13 (3.6) 17 (4.75) 34 (8.94) 0.002
Myocardial infarction, n (%) 3 (0.83) 4 (1.12) 8 (2.17) 0.121
Cerebrovascular accident, n (%) 3 (0.83) 9 (2.51) 10 (2.71) 0.072
Current smoking (%) 176 (48.75) 142 (39.05) 122 (32.53)  < 0.001
Regular exercise (%) 76 (21.11) 99 (27.22) 97 (25.74) 0.151
Body mass index, kg/m2 22.11 (2.19) 24.33 (2.21) 26.47 (2.63)  < 0.001
Waist circumference, cm 80.65 (6.40) 86.37 (5.92) 91.98 (6.19)  < 0.001
Systolic BP, mmHg 125.96 (16.15) 129.07 (17.15) 131.89 (17.58)  < 0.001
Diastolic BP, mmHg 82.86 (10.86) 84.55 (11.67) 86.70 (11.19)  < 0.001
Fasting glucose, mg/dL 94.17 (20.63) 99.82 (22.85) 102.37 (21.86)  < 0.001
HbA1c 5.51 (0.84) 5.65 (0.83) 5.79 (0.87)  < 0.001
HDL-cholesterol, mg/dL 48.58 (12.38) 45.02 (10.35) 43.12 (11.33)  < 0.001
LDL-cholesterol, mg/dL 107.58 (30.48) 114.75 (33.29) 119.25 (32.23)  < 0.001
Triglycerides, mg/dL 130.49 (93.56) 177.23 (134.73) 192.33 (106.79)  < 0.001
HOMA-IR, units 1.41 (1.11) 1.80 (1.32) 2.67 (3.04)  < 0.001
hs-CRP, mg/L 2.27 (7.78) 2.17 (4.81) 2.75 (4.99) 0.280
Baseline eGFR, mL/min/1.73m2 80.58 (10.66) 78.04 (9.93) 76.57 (11.42)  < 0.001
Follow-up eGFR, mL/min/1.73m2 85.25 (11.50) 82.03 (11.04) 81.18 (12.72)  < 0.001
Leptin, ng/L 1.15 (0.32) 2.20 (0.34) 4.79 (2.26)  < 0.001
Female
N (%) 510 510 526  
Age, years 54.43 (8.49) 53.97 (8.06) 54.01 (7.98) 0.416
Hypertension, n (%) 71 (14) 120 (23.45) 145 (27.61)  < 0.001
Diabetes mellitus, n (%) 30 (5.88) 47 (9.22) 35 (6.56) 0.698
Dyslipidemia, n (%) 18 (3.6) 24 (4.75) 47 (8.94) 0.004
Myocardial infarction, n (%) 6 (1.22) 12 (2.4) 12 (2.32) 0.215
Cerebrovascular accident, n (%) 6 (1.22) 6 (1.2) 5 (0.97) 0.703
Current smoking (%) 9 (1.78) 5 (0.99) 8 (1.52) 0.736
Regular exercise (%) 145 (28.46) 156 (30.65) 147 (27.86) 0.825
Body mass index, kg/m2 22.50 (2.24) 24.80 (2.47) 27.25 (3.01)  < 0.001
Waist circumference, cm 76.52 (7.18) 81.44 (7.28) 87.04 (8.17)  < 0.001
Systolic BP, mmHg 122.96 (17.29) 125.25 (17.57) 129.40 (17.77)  < 0.001
Diastolic BP, mmHg 80.11 (11.92) 81.49 (11.87) 83.63 (11.81)  < 0.001
Fasting glucose, mg/dL 91.21 (18.06) 93.94 (20.41) 93.12 (14.55) 0.088
HbA1c 5.48 (0.83) 5.59 (0.77) 5.66 (0.68)  < 0.001
HDL-cholesterol, mg/dL 48.71 (10.94) 47.52 (10.70) 47.44 (10.17) 0.055
LDL-cholesterol, mg/dL 113.12 (28.76) 124.34 (33.71) 128.49 (34.78)  < 0.001
Triglycerides, mg/dL 110.03 (65.86) 142.41 (84.75) 150.23 (83.54)  < 0.001
HOMA-IR, units 1.58 (0.81) 1.96 (1.10) 2.41 (1.27)  < 0.001
hs-CRP, mg/L 1.51 (3.38) 1.83 (4.25) 2.12 (4.22) 0.017
Baseline eGFR, mL/min/1.73m2 75.41 (8.85) 74.40 (8.00) 73.85 (9.59) 0.005
Follow-up eGFR, mL/min/1.73m2 79.42 (11.28) 78.13 (9.63) 77.43 (10.80) 0.002
Leptin, ng/L 4.20 (1.22) 7.88 (1.08) 14.86 (5.74)  < 0.001
Values are expressed as mean (SD) or number (%)
BP, blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein; TG, triglyceride; HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; hs-CRP, high sensitivity-C reactive protein; eGFR, estimated glomerular filtration rate