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Table 3 Clinical characteristics at recurrence, 12 months and last follow-up

From: Recurrence of IgA nephropathy after kidney transplantation: experience from the Swiss transplant cohort study

At time of recurrence

R group

NR group

All

Surveillance Bx.

Diagnostic Bx.

Clinical diagnosis

 

Number of patients

43

24

13

6

 on prednisone, N (%)

39 (90.7%)

23 (95.8%)

11 (84.6%)

5 (83.3%)

 on RAAS blockade, N (%)

27 (62.8%)

16 (66.7%)

7 (53.8%)

4 (66.7%)

Median eGFR (ml/min/1.73m2) [IQR]

53.4 [43.4, 64]

55.7 [43.4, 63.5]

44.1 [32.6, 53.8]

61.1 [48.4, 70.2]

Median proteinuriaa (mg/mmol) [IQR]

26.5 [13.8, 49]

19.5 [12.2, 35]

68.5 [30, 113]

14.5 [12.5, 36.8]

Patients with glomerular hematuria

24 (55.8%)

11 (45.8%)

7 (53.8%)

6 (100%)

 

At 12 months post-transplant follow-up visit

 Number of patientsb

29

21

6

2

130

  on prednisone, N (%)

26 (89.7%)

19 (90.5%)

6 (100%)

1 (50%)

102 (78.5%)

  on RAAS blockade, N (%)

16 (55.2%)

12 (57.1%)

2 (33.3%)

2 (100%)

75 (57.7%)

Median eGFR (ml/min/1.73m2) [IQR]

49.8 [38.5, 70.5]

49.8 [40.2, 69.7]

42.2 [22.9, 50.8]

82.4 [80, 84.9]

56.8 [43.5, 68.5]

Median proteinuriaa (mg/mmol) [IQR]

18 [8, 37.6]

13 [7, 24.6]

37.9 [23.5, 177.7]

34.1 [19.6, 48.5]

11 [6.2, 19.9]

Patients with glomerular hematuria

9 (31%)

6 (28.6%)

2 (33.3%)

1 (50%)

0

At last follow-up visitc

 Number of patients

43

24

13

6

118

  on prednisone, N (%)

34 (79.1%)

17 (70.8%)

11 (84.6%)

6 (100%)

76 (64.4%)

  on RAAS blockade, N (%)

31 (72.1%)

21 (87.5%)

6 (46.2%)

4 (66.7%)

76 (64.4%)

Median time to last follow-up visit (years) [IQR]

7 [5, 8.8]

7 [5.6, 8.3]

6.6 [2.7, 8.9]

7.1 [7, 7.7]

6 [4.3, 8]

Median eGFR (ml/min/1.73m2) [IQR]

46 [24.7, 65.3]

59.5 [38.4, 65.8]

19.6 [7.8, 46]

54.9 [43.4, 65.9]

52.6 [38.3, 68.9]

Median proteinuriaa (mg/mmol) [IQR]

27.9 [9.2, 108.5]

11.9 [9.2, 29.1]

69.7 [15.3, 140]

47.6 [18.9, 101.2]

12.5 [6.7, 28.5]

Patients with glomerular hematuria

22 (51.2%)

9 (37.5%)

8 (61.5%)

5 (83.3%)

0

  1. Abbreviations:TX transplantation, IQR interquartile range, IgAN IgA nephropathy, R recurrence, NR non-recurrence, RAAS renin-angiotensin-aldosterone system, eGFR estimated glomerular filtration rate, Bx biopsy
  2. aProteinuria is defined as protein to creatinine ratio
  3. bThere are two patients without 12 months post-transplant follow-up due to death or graft failure
  4. cThere are five patients with last follow-up visit within first 12 months post-transplant