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Table 5 Effect estimates from univariate and multivariable Cox proportional models for IgAN recurrence

From: Recurrence of IgA nephropathy after kidney transplantation: experience from the Swiss transplant cohort study

HR (95%-CI)

[p-value]

Univariate

Multivariable

Time-updated biomarker

Total IgA (mg/ml)

0.79 (0.59, 1.05) [0.11]

0.82 (0.62, 1.09) [0.18]

Total IgG (mg/ml)

1.003 (0.91, 1.11) [0.96]

1.004 (0.90, 1.12) [0.94]

Gd-IgA1 (OD)a

0.46 (0.006, 37.2) [0.73]

0.13 (0.001, 16.0) [0.41]

IgA-IgGIC (OD)

1.39 (0.24, 8.03) [0.72]

1.14 (0.20, 6.59) [0.88]

Recipient and transplant variables

Age at TX (years)

0.96 (0.94, 0.99) [0.002]

0.96 (0.93, 0.98) [0.001]

0.96 (0.93, 0.98) [0.001]

0.95 (0.93, 0.98) [0.001]

0.96 (0.93, 0.98) [0.001]

Female vs. Male

- short (≤ one-year)

2.83 (1.27, 6.35) [0.01]

2.49 (1.11, 5.61) [0.03]

2.52 (1.12, 5.67) [0.03]

2.67 (1.18, 6.07) [0.02]

2.52 (1.12, 5.66) [0.03]

- long (> one-year)

0.37 (0.05, 2.82) [0.34]

0.31 (0.04, 2.34) [0.25]

0.31 (0.04, 2.38) [0.26]

0.33 (0.04, 2.48) [0.28]

0.31 (0.04, 2.37) [0.26]

ATG/Thymoglobulin at TX

1.36 (0.63, 2.93) [0.44]

2.02 (0.88, 4.64) [0.10]

2.09 (0.90, 4.83) [0.09]

1.97 (0.85, 4.60) [0.12]

2.09 (0.90, 4.83) [0.09]

Deceased vs. living

0.94 (0.51, 1.74) [0.85]

1.28 (0.65, 2.52) [0.48]

1.25 (0.63, 2.47) [0.53]

1.22 (0.61, 2.42) [0.57]

1.24 (0.62, 2.47) [0.55]

HLA match vs. mismatch

0.76 (0.24, 2.46) [0.65]

0.96 (0.28, 3.27) [0.95]

0.93 (0.27, 3.20) [0.91]

0.96 (0.28, 3.27) [0.95]

0.93 (0.27, 3.17) [0.91]

Prior kidney TX

1.23 (0.55, 2.78) [0.61]

RAAS exposure

1.63 (0.87, 3.08) [0.13]

Prednisone intake

1.13 (0.50, 2.56) [0.76]

  1. Abbreviations:HR hazard ratio, CI confidence interval, IgAN IgA nephropathy, ATG anti-thymocyte globulin, HLA human leukocyte antigen, RAAS renin-angiotensin-aldosterone system
  2. aFor Gd-IgA1 (OD) baseline values only are included in the multivariable model