First case of a renal cyst infection caused by Desulfovibrio: a case report and literature review

Okamoto, Yoshiki; Miyabe, Yoei; Seki, Momoko; Ushio, Yusuke; Sato, Keisuke; Kasama, Eri; Akiyama, Kenichi; Karasawa, Kazunori; Uchida, Keiko; Kikuchi, Ken; Nitta, Kosaku; Moriyama, Takahito; Hoshino, Junichi

doi:10.1186/s12882-022-02803-w

BMC Nephrology

Table 1 Characteristics of 72 cases infected with Desulfovibrio species in 27 articles

From: First case of a renal cyst infection caused by Desulfovibrio: a case report and literature review

Case no.	Age (yrs)	Sex	Infection	Source	Genus/species	Co-isolated/co-infected organism(s)	Identification	Time for positive incubation	Antibiotic susceptibility (Susceptible)	Antibiotic therapy	Outcome	Ref.
1	39	M	Sinusitis, gingivitis, brain abscess	Pus	D. desulfuricans	Streptococcus constellatus, Capnocytophaga ochracea, Cubacterium exiguum	Biochemical	10 days	AMC, IPM, MNZ	CTX, FOF, ONZ, PIP, PEF	Survived	[3, 13]
2	3	F	Appendix abscess	Pus	D. desulfuricans	B. merdae, E. lentum, E. coli, Enterococcus sp.	16S rDNA	unknown	unknown	unknown	Survived	[3]
3	61	F	Abdominal wall abscess, peritonitis	Pus	D. desulfuricans	B. fragilis, E. lentum, Clostridium sp., E. coli, Enterobacter cloacae, Enterococcus sp.	16S rDNA	unknown	unknown	unknown	Survived
3	61	F	Abdominal wall abscess, peritonitis	Blood	D. desulfuricans	E. coli, Enterobacter cloacae	16S rDNA	unknown	unknown	unknown	Survived
4	80	M	Peritonitis	Peritoneal fluid	D. desulfuricans	unknown	16S rDNA	unknown	unknown	unknown	unknown	[14]
5	64	M	Bacteraemia	Blood	D. desulfuricans	None	16S rDNA	6 days	LVX, MXF, GAT, MNZ, CLI, IPM, ETP, DOX	DOX	Survived	[1]
6–8	unknown	unknown	unknown	unknown	D. desulfuricans	unknown	unknown	unknown	unknown	unknown	unknown	[4]
9	86	F	Bacteraemia, sacral decubitus ulcer	Blood	D. desulfuricans	E. lenta	16S rDNA	5 days	AMX, AMC, CLI, IPM, MNZ	CXM, AMX	Survived	[15]
10	60	M	Bacteraemia	Blood	D. desulfuricans	None	16S rDNA	8 days	unknown	CRO, ERY, PIP	Survived	[16]
11	69	F	Bacteraemia, ulcerative colitis	Blood	D. desulfuricans	Cytomegalovirus	16S rDNA	7 days	CLI, MNZ, ERY, AMC, MEM	PIP, CLI	Survived	[17]
12	87	M	Bacteraemia, colitis	Blood	D. desulfuricans	None	16S rDNA	12 days	SAM, TZP, AMC, FEP, MEM	SAM, CFZ, CAZ, CZO	Survived	[18]
13	69	M	Bacteraemia	Blood	D. desulfuricans	None	16S rDNA	5 days	IPM, MNZ	OFX, TZP	Survived	[19]
14	66	F	Hydronephrosis, suspected colon-ureteral/vesical fistula	Urine from percutaneous nephrostomy	D. desulfuricans	Anaerobic Gram-positive bacilli, anaerobic Gram-positive cocci, Streptococcus agalactiae, Actinobaculum schaalii, Propionimicrobium spp.	16S rDNA	unknown	CLI, MNZ, PEN	unknown	Died, secondary to herpes encephalitis	[20]
15	76	M	Bacteraemia, diverticulitis	Blood	D. desulfuricans	None	16S rDNA	3 days	MNZ	unknown	Survived
16	60	M	Colonic rupture	Spine tissue	D. desulfuricans	Mobiluncus curtisii, Candida albicans, Clostridium clostridioforme	16S rDNA	unknown	CLI, MNZ, PEN	unknown	Died
17	74	F	Bacteraemia, small-bowel obstruction	Blood	D. desulfuricans	None	16S rDNA	3 days	CLI, MNZ, TZP, ETP	unknown	Survived
18	57	M	Perforated acute appendicitis	Blood	D. desulfuricans	In peritoneal fluid: E. coli, K. pneumoniae, anaerobic Gram-negative and -positive rods	16S rDNA	4 days	CLI, MNZ, SAM, ETP	unknown	Survived
19	82	M	Bacteraemia, liver abscess	Blood	D. desulfuricans	None	Biochemical, 16S rDNA	15 days	AMP, AMC, IPM, PAPM, CLI, LVX	CMZ, TZP, AMC	Survived	[21]
20	73	F	Sepsis, liver abscess	Blood, pus	D. desulfuricans	E. coli	16S rDNA	3 days	LVX, MEM, SAM	MEM, SBT/CPZ, SAM, SBTPC	Survived	[22]
21	88	M	Bacteraemia, mediastinal abscess	Blood	D. desulfuricans	None	16S rDNA	3 days	unknown	TZP, CLDM, MNZ	Survived	[10]
22	53	M	Bacteraemia	Blood	D. desulfuricans	None	MALDI-TOF MS	3 days	MNZ, AMC, IPM, CLI	AMC, TZP	Survived	[23]
23	53	F	Trochanteric arthritis	Synovial fluid	D. desulfuricans	None	MALDI-TOF MS	6 days	MNZ, AMC	FEP, VAN, CRO, MNZ	Survived	[24]
24	67	M	Cholecystitis	Blood	D. fairfieldensis(*)	None	Biochemical	unknown	PEN, CLI, CHL, TET, ERY	None	Survived	[11]
25	82	M	Liver abscess	Pus	D. fairfieldensis	Fusobacterium varium	16S rDNA	7 days	MNZ	CTX, MNZ, AMP, CIP	Survived	[6]
26	75	M	Bleeding colonic polyps	Blood	D. fairfieldensis	None	16S rDNA	6 days	MNZ, CHL, CIP, IPM, AMC, TIM, AZM, CLI	LEX, CIP	Survived	[12]
27	46	F	Meningoencephalitis	Urine	D. fairfieldensis	None	16S rDNA	14 days	IPM, CIP, RIF, CLI, MNZ, CHL	AMP, RIF, EMB, INH, ACV, anti-mycobacterial drugs	Died	[5]
28	23	M	Perforating appendicitis, peritonitis	Blood	D. fairfieldensis	None	Biochemical, 16S rDNA	5 days	MNZ, IPM, CLI	FAM, MNZ	Survived	[3]
29	59	F	Intra-abdominal abscess	Pus	D. fairfieldensis	B. vulgatus, E. lentum, E. coli, K. pneumoniae, Streptococcus intermedius	16S rDNA	unknown	MNZ, CLI	unknown	Survived
30	85	M	Abdominal abscess	Blood	D. fairfieldensis	B. fragilis, B. uniformis, B. vulgatus, B. thetaiotaomicron, Clostridium innocuum, Clostridium sp., Enterococcus avium	16S rDNA	unknown	MNZ, CLI	unknown	Survived
31	65	M	Abdominal wall abscess	Pus	D. fairfieldensis	B. thetaiotaomicron, E. lentum, E. coli, K. pneumoniae, Proteus vulgaris, Enterococcus sp., Streptococcus intermedius	16S rDNA	unknown	MNZ, CLI	unknown	Survived
32	32	M	Appendicitis, peritonitis	Peritoneal fluid	D. fairfieldensis	unknown	16S rDNA	unknown	unknown	unknown	unknown
33	29	F	Appendicitis, peritonitis	Peritoneal fluid	D. fairfieldensis	unknown	16S rDNA	unknown	unknown	unknown	unknown
34	53	F	Peritonitis	Peritoneal fluid	D. fairfieldensis	unknown	16S rDNA	unknown	unknown	unknown	unknown
35	21	M	Appendicitis	Intra-abdominal collection	D. fairfieldensis	unknown	16S rDNA	unknown	unknown	unknown	unknown
36–45	unknown	unknown	unknown	unknown	D. fairfieldensis	unknown	unknown	unknown	unknown	unknown	unknown	[4]
46	77	M	Aftercholangiopancreatography	Blood	D. fairfieldensis	None	16S rDNA	4 days	MNZ, CIP	TIM, CIP	Survived	[2]
47	69	F	Bacteraemia	Blood	D. fairfieldensis	E. coli, Morganella morganii	16S rDNA	9 days	MNZ, CLI, IPM, BIPM, DOR	BIPM, CFZ	Survived	[7]
48	83	M	Bacteraemia, epidural abscess	Blood	D. fairfieldensis	Parvimonas micra	MALDI-TOF MS, 16S rDNA	7 days	None	None	Survived	[25]
49	63	M	Renal cyst infection	Pus	D. fairfieldensis	None	16S rDNA	None	None	MEM, MNZ	Survived	This
50	64	M	Peritonitis	Peritoneal fluid	D. piger	unknown	16S rDNA	unknown	unknown	unknown	unknown	[14]
51	83	F	Peritonitis	Peritoneal fluid	D. piger	unknown	16S rDNA	unknown	unknown	unknown	unknown
52	81	F	Rectal cancer	Peritoneal fluid	D. piger	unknown	16S rDNA	unknown	unknown	unknown	unknown
53	88	F	Peritonitis	Peritoneal fluid	D. piger	unknown	16S rDNA	unknown	unknown	unknown	unknown
54	14	M	Appendicitis	Abdominal collection	D. piger	unknown	16S rDNA	unknown	unknown	unknown	unknown
55	18	M	Peritonitis	Peritoneal fluid	D. piger	unknown	16S rDNA	unknown	unknown	unknown	unknown
56	9	M	Appendicitis, peritonitis	Peritoneal fluid	D. piger	unknown	16S rDNA	unknown	unknown	unknown	unknown
57–58	unknown	unknown	unknown	unknown	D. piger	unknown	unknown	unknown	unknown	unknown	unknown	[4]
59	73	F	Bacteraemia, abdominal abscess	Blood	D. piger	E. lenta, B. ovatus	16S rDNA	2 days	CLI, MNZ	unknown	Survived	[20]
60	63	M	Perforated acute appendicitis	Peritoneal fluid	D. piger	E. coli, Enterococcus sp., anaerobic Gram-negative rod	16S rDNA	unknown	unknown	unknown	Survived	[20]
61	unknown	unknown	Abdominal abscess	Peritoneal fluid	D. vulgaris	None	unknown	unknown	unknown	unknown	unknown	[26]
62–64	unknown	unknown	unknown	unknown	D. vulgaris	unknown	unknown	unknown	unknown	unknown	unknown	[4]
65	15	M	Brain abscess	Pus	D. vulgaris	Gram-positive cocci	Biochemical	2 days	KAN	AMC, CRO, AMK, LZD	Survived	[27]
66	70	F	Left-shoulder prosthetic-joint infection	Synovial fluid, prosthetic joint	D. legallii	None	16S rDNA	10 days	CLI, MNZ, ETP, AMC, CRO	unknown	Survived	[20]
67	unknown	unknown	Acute appendicitis	Peritoneal fluid	Desulfovibrio sp.	unknown	Biochemical	unknown	unknown	unknown	unknown	[28]
68	unknown	unknown	Perforating appendicitis	Peritoneal fluid	Desulfovibrio sp.	unknown	Biochemical	unknown	unknown	unknown	unknown	[28]
69	60	M	Perforated acute appendicitis	Blood	Desulfovibrio sp.	E. lenta, anaerobic Gram-negative rod, B. fragilis	16S rDNA	3 days	CLI, MNZ	unknown	Survived	[20]
70	74	M	Septic shock, intra-abdominal infection	Blood	Desulfovibrio sp.	Candida parapsilosis	16S rDNA	5 days	unknown	unknown	Died
71	45	M	Subphrenic abscess, abdominal infection	Blood	Desulfovibrio sp.	In subphrenic abscess: vancomycin-resistant enterococci	16S rDNA	5 days	unknown	unknown	Survived
72	93	F	Sigmoid diverticulitis	Blood	Desulfovibrio sp.	None	16S rDNA	6 days	CLI, MNZ	unknown	Died

(*) Although a human infection of Desulfovibrio species (specifically D. desulfuricans, presented as bacteraemia associated with cholecystitis) was first reported in 1987, the strain was considered as D. fairfieldensis in 2005
Ref Reference, M male, F female, MALDI-TOF MS Matrix-assisted laser desorption ionization time-of-flight mass spectrometry, B Bacteroides, D Desulfovibrio, E. coli Escherichia coli, E. lenta Eggerthella lenta, E. lentum Eubacterium lentum, K Klebsiella, ACV acyclovir, AMC amoxicillin-clavulanic acid, AMK amikacin, AMP ampicillin, AMX amoxicillin, AZM azithromycin, BIPM biapenem, CAZ ceftazidime, CFZ cefazolin, CHL chloramphenicol, CIP ciprofloxacin, CLI clindamycin, CMZ cefmetazole, CRO ceftriaxone, CTX cefpodoxime, CXM cefuroxime, CZO cefozopran, DOR doripenem, DOX doxycycline, EMB ethambutol, ERY erythromycin, ETP ertapenem, FAM cefamandole, FEP cefepime, FOF fosfomycin, GAT gatifloxacin, INH isoniazid, IPM imipenem, KAN kanamycin, LVX levofloxacin, LZD linezolid, MEM meropenem, MNZ metronidazole, MXF moxifloxacin, OFX ofloxacin, ONZ ornidazole, PAPM panipenem, PEF pefloxacin, PEN penicillin, PIP piperacillin, RIF rifampin, SAM ampicillin-sulbactam, SBT/CPZ Cefoperazone sodium and sulbactam sodium, SBTPC sultamicillin, TET tetracycline, TIM ticarcillin-clavulanic acid, TZP piperacillin-tazobactam, VAN vancomycin

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