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Table 2 Literature review: pathologic featuresĀ and clinical presentations of ā€œnon-lupus full-house nephropathyā€ (NLFHN)

From: Bartonella endocarditis and diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition

Groups

Pathologic Diagnosis

Cases

Light Microscopy Pattern

Location of Deposits by EM

Clinical Presentation

Literature

Ā 

Idiopathic

1

Minimal change

1

Minimal lesion pattern

mes and subendo

normal urinalysis (donor kidney at 0ā€‰hour biopsy)

#26

2

Ā 

NA

NS

#25

1

Ā 

mes

NS

#27

2

Mesangial proliferative GN

1

Mesangial proliferative pattern

NA

SubNS, hematuria

#25

1

Ā 

NA

NS and nephritic

#28

1

Ā 

mes

SubNS

#24

3

Focal proliferative GN

5

Focal proliferative pattern

2 subepi; 1 TM and subepi; 2 NA

NS; or NS and hematuria

#25

2

Ā 

mes, subendo, subepi

NS

#23

4

Diffuse proliferative GN

2

Diffuse proliferative pattern

NA

RPGN, NS, malignant HTN

#25

1

Ā 

NA

SubNS, hypertension

#29

7

Ā 

NA

NS; or subNS; or NS and nephritic; or RPGN

#28

10

Ā 

NA

NS; or nephritic; or NS and nephritic; or CRF

#30

7

Ā 

mes, subendo, subepi

NS or subNS, hematuria, renal insufficiency

#23

5

Diffuse proliferative GN with crescents

2

Diffuse proliferative with crescents

mes, subendo, subepi; subepi

RPGN, subNS, hematuria, malignant HTN

#25

10

Ā 

NA

NA

#30

2

Ā 

mes, subendo, subepi

SubNS and hematuria

#22

1

Ā 

mes, subendo, subepi

SubNS, hematuria and renal insufficiency

#23

6

MPGN

1

Membranoproliferative pattern

mes, subendo, subepi

NS

#25

2

Ā 

NA

NS and nephritic

#28

3

Ā 

mes and subendo

RPGN; chronic renal failure;or NS

#24

1

Ā 

NA

NS and nephritic

#29

12

Ā 

NA

RPGN; or NS; or NS and nephritic

#30

1

Ā 

mes, subendo, subepi

NS, hemturia

#22

3

Ā 

mes, subendo, subepi

NS, hematuria

#23

7

MN

1

Membranous pattern

NA

NS, renal insufficiency

#29

2

Ā 

NA

1 NS; 1 NS and nephritic

#28

10

Ā 

subepi

NS; or subNS

#24

21

Ā 

NA

NS; or subNS with nephritic

#30

4

Ā 

mes, subendo, subepi

NS or subNS

#23

8

Diffuse proliferative GN with MN

1

Diffuse proliferative and membranous patterns

mes, subendo, subepi

NS, hematuria, renal insufficiency

#22

9

FSGS

2

Segmental chronic lesions

1 mes, subendo, subepi; 1 NA

NS

#25

10

FSGS with TMA

1

Segmental chronic lesions and TMA

NA

NS

#25

11

C1q nephropathy

1

Diffuse proliferative pattern

mes and subendo

NS

#24

3

Proliferative GN in 1; minima change in 2

NA

NA

#30

12

IgA nephropathy

1

Segmental chronic lesions

NA

SubNS and hematuria

#25

3

Focal mesangial proliferative pattern

mes

NS; SubNS; or chronic renal failure

#24

16

Mesangial proliferative pattern

NA

NA

#30

13

IgA nephropathy with crescents

3

Focal or diffuse proliferative pattern with crescents

1 subendo; 2 NA

SubNS, hematuria, RPGN, malignant HTN

#25

2

Focal or diffuse proliferative patternĀ with crescents

mes

RPGN

#24

Ā 

Secondary

14

Infection-related GN

1

Minimal lesionĀ pattern

mes and subendo

Microalbuminemia, hematuria

#25

1

Diffuse proliferative pattern

mes, subendo, TM, subepi humps

RPGN

#25

15

Infecious endocarditis-related GN

1

Diffuse proliferative pattern

subepithelial humps

MSSA infectious endocarditis

#24

16

Post-streptocococal GN

2

Diffuse proliferative pattern

subepithelial humps

Nephritic; or NS

#24

17

IgA-dominant infection-related GN

2

Diffuse mesangial proliferative pattern

NA

NA

#30

1

Diffuse proliferative pattern

subepithelial humps

Nephritic

#24

18

HBV-associated MN

1

Membranous pattern

subepi

NS

#24

1

Membranous pattern

NA

NS

#30

19

HIV-associated immune complex GN (6 cases with concurrent HCV infection)

6

Focal proliferative pattern

mes, subendo, subepi

NS or subNS, hematuria, renal insufficiency, 1 HCV+

#31

7

Diffuse proliferative pattern

mes, subendo, subepi

NS or subNS, hematuria, renal insufficiency, 4 HCV+

#31

1

Membranous pattern

subepi, TM, subendo, mes

NS, HCV+

#31

20

ANCA-associated GN

2

Diffuse proliferative patternĀ with crescents

NA

RPGN; or subNS and hematuria

#25

1

Membranoproliferative patternĀ with crescents

NA

RPGN, HTN crisis, p-ANCA positive

#32

21

Amyloidosis

7

Amyloid protein deposition

NA

NA

#30

22

Cancer-associated MN

3

Membranous, anti-PLA2R negative

1 mes, subepi; 2 subepi

NS; or subNS and hematuria; all with cancer

#25

23

Glomerular disease in IPEX patient

1

Membranous with focal proliferative pattern

mes, subendo, subepi

NS, hematuria

#33

  1. Abbreviations: ANCA anti-neutrophil cytoplasmic antibody, EM electron microscopy, C1q complement 1q, FSGS focal segmental glomerulosclerosis, GN glomerulonephritis, HBV hepatitis B virus, HIV human immmunodeficiency virus, HCV hepatitis C virus, IgA immunoglobulin A, MN membranous nephropathy, MPGN membranoproliferative glomerulonephritis, MSSA methicillin-susceptible Staphylococcus aureus, NS nephrotic syndrome, IPEX immunodysregulation, polyendocrinopathy, enteropathy, X-linked, Mes mesangial, NA not available, RPGN rapidly progressive glomerulonephritis, Subendo subendothelial, SubNS subnephrotic, Subepi subepithelial, TM transmembrane, TMA thrombotic microangiopathy