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Table 2 Literature review: pathologic features and clinical presentations of “non-lupus full-house nephropathy” (NLFHN)

From: Bartonella endocarditis and diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition

Groups Pathologic Diagnosis Cases Light Microscopy Pattern Location of Deposits by EM Clinical Presentation Literature
  Idiopathic
1 Minimal change 1 Minimal lesion pattern mes and subendo normal urinalysis (donor kidney at 0 hour biopsy) #26
2   NA NS #25
1   mes NS #27
2 Mesangial proliferative GN 1 Mesangial proliferative pattern NA SubNS, hematuria #25
1   NA NS and nephritic #28
1   mes SubNS #24
3 Focal proliferative GN 5 Focal proliferative pattern 2 subepi; 1 TM and subepi; 2 NA NS; or NS and hematuria #25
2   mes, subendo, subepi NS #23
4 Diffuse proliferative GN 2 Diffuse proliferative pattern NA RPGN, NS, malignant HTN #25
1   NA SubNS, hypertension #29
7   NA NS; or subNS; or NS and nephritic; or RPGN #28
10   NA NS; or nephritic; or NS and nephritic; or CRF #30
7   mes, subendo, subepi NS or subNS, hematuria, renal insufficiency #23
5 Diffuse proliferative GN with crescents 2 Diffuse proliferative with crescents mes, subendo, subepi; subepi RPGN, subNS, hematuria, malignant HTN #25
10   NA NA #30
2   mes, subendo, subepi SubNS and hematuria #22
1   mes, subendo, subepi SubNS, hematuria and renal insufficiency #23
6 MPGN 1 Membranoproliferative pattern mes, subendo, subepi NS #25
2   NA NS and nephritic #28
3   mes and subendo RPGN; chronic renal failure;or NS #24
1   NA NS and nephritic #29
12   NA RPGN; or NS; or NS and nephritic #30
1   mes, subendo, subepi NS, hemturia #22
3   mes, subendo, subepi NS, hematuria #23
7 MN 1 Membranous pattern NA NS, renal insufficiency #29
2   NA 1 NS; 1 NS and nephritic #28
10   subepi NS; or subNS #24
21   NA NS; or subNS with nephritic #30
4   mes, subendo, subepi NS or subNS #23
8 Diffuse proliferative GN with MN 1 Diffuse proliferative and membranous patterns mes, subendo, subepi NS, hematuria, renal insufficiency #22
9 FSGS 2 Segmental chronic lesions 1 mes, subendo, subepi; 1 NA NS #25
10 FSGS with TMA 1 Segmental chronic lesions and TMA NA NS #25
11 C1q nephropathy 1 Diffuse proliferative pattern mes and subendo NS #24
3 Proliferative GN in 1; minima change in 2 NA NA #30
12 IgA nephropathy 1 Segmental chronic lesions NA SubNS and hematuria #25
3 Focal mesangial proliferative pattern mes NS; SubNS; or chronic renal failure #24
16 Mesangial proliferative pattern NA NA #30
13 IgA nephropathy with crescents 3 Focal or diffuse proliferative pattern with crescents 1 subendo; 2 NA SubNS, hematuria, RPGN, malignant HTN #25
2 Focal or diffuse proliferative pattern with crescents mes RPGN #24
  Secondary
14 Infection-related GN 1 Minimal lesion pattern mes and subendo Microalbuminemia, hematuria #25
1 Diffuse proliferative pattern mes, subendo, TM, subepi humps RPGN #25
15 Infecious endocarditis-related GN 1 Diffuse proliferative pattern subepithelial humps MSSA infectious endocarditis #24
16 Post-streptocococal GN 2 Diffuse proliferative pattern subepithelial humps Nephritic; or NS #24
17 IgA-dominant infection-related GN 2 Diffuse mesangial proliferative pattern NA NA #30
1 Diffuse proliferative pattern subepithelial humps Nephritic #24
18 HBV-associated MN 1 Membranous pattern subepi NS #24
1 Membranous pattern NA NS #30
19 HIV-associated immune complex GN (6 cases with concurrent HCV infection) 6 Focal proliferative pattern mes, subendo, subepi NS or subNS, hematuria, renal insufficiency, 1 HCV+ #31
7 Diffuse proliferative pattern mes, subendo, subepi NS or subNS, hematuria, renal insufficiency, 4 HCV+ #31
1 Membranous pattern subepi, TM, subendo, mes NS, HCV+ #31
20 ANCA-associated GN 2 Diffuse proliferative pattern with crescents NA RPGN; or subNS and hematuria #25
1 Membranoproliferative pattern with crescents NA RPGN, HTN crisis, p-ANCA positive #32
21 Amyloidosis 7 Amyloid protein deposition NA NA #30
22 Cancer-associated MN 3 Membranous, anti-PLA2R negative 1 mes, subepi; 2 subepi NS; or subNS and hematuria; all with cancer #25
23 Glomerular disease in IPEX patient 1 Membranous with focal proliferative pattern mes, subendo, subepi NS, hematuria #33
  1. Abbreviations: ANCA anti-neutrophil cytoplasmic antibody, EM electron microscopy, C1q complement 1q, FSGS focal segmental glomerulosclerosis, GN glomerulonephritis, HBV hepatitis B virus, HIV human immmunodeficiency virus, HCV hepatitis C virus, IgA immunoglobulin A, MN membranous nephropathy, MPGN membranoproliferative glomerulonephritis, MSSA methicillin-susceptible Staphylococcus aureus, NS nephrotic syndrome, IPEX immunodysregulation, polyendocrinopathy, enteropathy, X-linked, Mes mesangial, NA not available, RPGN rapidly progressive glomerulonephritis, Subendo subendothelial, SubNS subnephrotic, Subepi subepithelial, TM transmembrane, TMA thrombotic microangiopathy