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Table 2 Prognostic analysis of AKD associated with 1-year primary and secondary outcomes

From: Association of acute kidney disease with the prognosis of ischemic stroke in the Third China National Stroke Registry

 

sCr based AKD

eGFRsCr based AKD

eGFRsCysC based AKD

eGFRsCr+sCysC based AKD

AKD

n = 198

non-AKD

n = 4867

P

AKD

n = 337

non-AKD

n = 4728

P

AKD

n = 500

non-AKD

n = 4565

P

AKD

n = 314

non-AKD

n = 4751

P

All-cause deatha, n(%)

8 (4.0)

63(1.3)

 

12(3.6)

59(1.3)

 

9(1.8)

62(1.4)

 

9(2.9)

62(1.3)

 

Crude HR (95% CI)

3.15(1.51–6.58)

ref

0.002

2.88(1.55–5.36)

ref

 < 0.001

1.33(0.66–2.67)

ref

0.43

2.21(1.10–4.44)

ref

0.03

Adjusted HR (95% CI)d

2.67(1.27–5.61)

ref

0.01

2.19(1.17–4.10)

ref

0.02

1.01(0.50–2.05)

ref

0.97

1.86(0.92–3.76)

ref

0.08

Stroke recurrenceb, n(%)

9(4.6)

175(3.6)

 

17(5.0)

167(3.5)

 

19(3.8)

165(3.6)

 

11(3.5)

173(3.6)

 

Crude HR (95% CI)

1.28(0.65–2.49)

ref

0.48

1.45(0.88–2.39)

ref

0.14

1.05(0.66–1.69)

ref

0.83

0.97(0.53–1.78)

ref

0.91

Adjusted HR (95% CI)d

1.22(0.62–2.39)

ref

0.56

1.35(0.82–2.23)

ref

0.25

0.94(0.58–1.52)

ref

0.80

0.91(0.49–1.68)

ref

0.76

Stroke disabilityc, n(%)

32(16.2)

459(9.4)

 

56(16.6)

435(9.2)

 

69(13.8)

422(9.2)

 

42(13.4)

449(9.5)

 

Crude OR (95% CI)

1.85(1.25–2.74)

ref

0.002

1.97(1.45–2.66)

ref

 < 0.001

1.57(1.20–2.07)

ref

0.001

1.48(1.05–2.08)

ref

0.02

Adjusted OR (95% CI)d

1.60(1.04–2.44)

ref

0.03

1.51(1.08–2.11)

ref

0.02

1.20(0.89–1.62)

ref

0.23

1.26(0.88–1.82)

ref

0.21

  1. AKD Acute kidney disease, sCr Serum creatinine, sCysC Serum cystatin C, eGFR Estimated glomerular filtration rate, CI Confidence interval, OR Odds ratio, HR Hazard ratio, mRS Modified Rankin Scale, NIHSS National Institutes of Health stroke scale, TOAST Trial of Org 10,172 in Acute Stroke Treatment
  2. aAll-cause death, defined as all-cause death occurred from 3-month to 1-year
  3. bStroke recurrence defined as stroke recurrence occurred from 3-month to 1-year
  4. cStroke disability, defined as a mRS score of 3–6 at 1-year
  5. dAdjusted factors in multivariable analysis: age, gender, TOAST subtypes, mRS and NIHSS on admission, history of diabetes, hypertension, coronary heart disease