Fig. 2

Conceptual model of signs/symptoms and impacts identified in patients with stages 2–3b CKD from patient interviews. Identified signs/symptoms and impacts were grouped into 12 categories, represented by purple headings. New or updated concepts following concept elicitation interviews are indicated by a coloured circle or diamond. Concepts without an orange circle were identified during the TLR [35]. Concepts shown in bold were salient (≥ 50% of patients mentioned the concept and provided an average bothersomeness rating of ≥ 5.0). (CKD, chronic kidney disease; TLR, targeted literature review)