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Table 3 AKI’s Odds ratio for hemoglobin drop as a continuous variable, as a categorical variable by IQR or cut-point in crude and adjusted models in total and stratified datasets

From: Threshold heterogeneity of perioperative hemoglobin drop for acute kidney injury after noncardiac surgery: a propensity score weighting analysis

 

Model 1

Model 2

Full model

AKI aOR (95% CI)

P-value

AKI aOR (95% CI)

P-value

AKI aOR (95% CI)

P-value

Full dataset

Continous HGBd

1.01 (1.01—1.01)

 < .001

1.01 (1.01—1.01)

 < .001

1.02 (1.01—1.02)

 < .001

HGBd quintile, g/L

   < 4

reference

 

reference

 

reference

 

  4—10

1.20 (1.03—1.38)

0.012

1.16 (1.00—1.33)

0.039

1.31 (1.12—1.51)

 < .001

  10—17

1.16 (1.00—1.32)

0.031

1.14 (0.98—1.30)

0.06

1.40 (1.20—1.60)

 < .001

  17—25

1.26 (1.08—1.44)

0.001

1.21 (1.04—1.38)

0.008

1.57 (1.33—1.80)

 < .001

   > 25

1.33 (1.14—1.51)

 < .001

1.26 (1.08—1.44)

0.001

1.65 (1.38—1.92)

 < .001

HGBd cut-point before PSW

reference

 < .001

reference

 < .001

reference

 < .001

   ≤ 43

   > 43

1.77 (1.42—2.13)

1.80 (1.44—2.17)

1.82 (1.42—2.21)

HGBd cut-point after PSW

reference

 < .001

reference

 < .001

reference

 < .001

   ≤ 43

   > 43

2.66 (1.78—3.97)

2.68 (1.79—4.02)

3.29 (2.00—5.40)

Patient with preoperative anemia

Continous HGBd

1.02 (1.01—1.02

 < .001

1.02 (1.01—1.02

 < .001

1.01 (1.01—1.02)

 < .001

HGBd quintile, mmHg

   < 0

reference

 

reference

 

reference

 

  0—6

1.26 (0.97—1.55)

0.053

1.15 (0.88—1.42)

0.238

1.15 (0.88—1.43)

0.247

  6—12

1.24 (0.96—1.52)

0.064

1.13 (0.87—1.39)

0.293

1.12 (0.86—1.38)

0.343

  12—20

1.26 (0.97—1.54)

0.049

1.15 (0.88—1.41)

0.244

1.14 (0.87—1.40)

0.278

   > 20

1.73 (1.35—2.12)

 < .001

1.64 (1.27—2.00)

 < .001

1.50 (1.14—1.86)

0.001

HGBd cut-point before PSW

reference

 < .001

reference

 < .001

reference

 < .001

   ≤ 18

   > 18

1.48 (1.24—1.71)

1.47 (1.24—1.71)

1.38 (1.14—1.62

 HGBd cut-point after PSW

reference

 < .001

reference

 < .001

reference

 < .001

   ≤ 18

   > 18

1.42 (1.17—1.72)

1.42 (1.17—1.72)

1.42 (1.17—1.74)

Patient without preoperative anemia

Continous HGBd

1.01 (1.01—1.02

 < .001

1.01 (1.01—1.02)

 < .001

1.01 (1.01—1.02)

 < .001

HGBd quintile, mmHg

   < 5

reference

 

reference

 

reference

 

  5—12

1.52 (1.22—1.82)

 < .001

1.49 (1.19—1.78)

 < .001

1.52 (1.22—1.82)

 < .001

  12—18

1.67 (1.34—2.01)

 < .001

1.64 (1.32—1.97)

 < .001

1.68 (1.35—2.02)

 < .001

  18—26

1.60 (1.28—1.92)

 < .001

1.56 (1.24—1.87)

 < .001

1.61 (1.27—1.94)

 < .001

   > 26

1.92 (1.55—2.30)

 < .001

1.83 (1.47—2.18)

 < .001

1.86 (1.46—2.26)

 < .001

HGBd cut-point before PSW

reference

 < .001

reference

 < .001

reference

 < .001

   ≤ 43

   > 43

1.96 (1.52—2.41)

1.91 (1.48—2.35)

1.81 (1.35—2.27)

HGBd cut-point after PSW

reference

 < .001

reference

 < .001

reference

 < .001

   ≤ 43

   > 43

2.68 (1.76—4.07)

2.68 (1.76—4.08)

2.88 (1.85—4.50)

  1. Model 1: Crude model
  2. Model 2: Crude model + age, gender
  3. Full model: Model 2 + hypertension, preoperative albumin level, cancer surgery, intraperitoneal surgery, intraoperative blood transfusion, intraoperative hypotension, intraoperative dexmedetomidine and colloid use
  4. HGBd Hemoglobin drop, the difference between preoperative mean hemoglobin and perioperative minimal hemoglobin, g/L
  5. aOR adjusted odds ratio of AKI for hemoglobin drop
  6. CI Confidence Interval
  7. PSW Propensity Score Weighting
  8.  >