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Table 1 Patient characteristics and clinical outcomes

From: Elevated parathyroid hormone one year after kidney transplantation is an independent risk factor for graft loss even without hypercalcemia

 

HPT-free

N = 493

NC-HPT

N = 399

P-value

Baseline characteristics

 Recipient age (years)

43 (31–57)

45 (36–59)

0.012*

 Recipient sex (male, %)

321 (65.1)

251 (62.9)

0.540

 Body mass index (kg/m2)

21.3 (19.4–23.6)

22.3 (19.8–25.0)

0.001*

 Dialysis vintage (months)

4 (0–21)

7 (0–38)

0.009*

 Preemptive KTx (%)

190 (38.5)

144 (36.1)

0.495

 Diabetes mellitus (%)

104 (21.1)

87 (21.8)

0.861

 Living/deceased donor (%)

483 (98.0)/10 (2.0)

386 (96.7)/13 (3.3)

0.347

 Donor age (years)

57 (50–62)

60 (51–65)

< 0 .001*

 Donor sex (male, %)

181 (36.8)

134 (33.6)

0.355

 HLA AB mismatch

2 (1–3)

2 (1–3)

0.234

 HLA DR mismatch

1 (1–2)

1 (1–2)

0.293

 Preformed DSA (%)

28 (5.8)

21 (5.3)

0.902

 ABO blood type incompatible KTx (%)

132 (26.8)

124 (31.1)

0.181

Lab data one year post KTx

 Corrected calcium (mg/dL)

9.8 (9.6–10.0)

9.7 (9.4–10.0)

< 0.001*

 Phosphorus (mg/dL)

3.4 (3.0–3.7)

3.3 (2.9–3.6)

0.013*

 Intact PTH (pg/mL)

55.0 (43.0–66.0)

104.0 (91.0–136.0)

< 0.001*

 eGFR (mL/min/1.73m2)

46.2 (39.2–53.6)

42.1 (34.7–50.4)

< 0.001*

 MBP one year post KTx (mmHg)

90.7 (83.0–98.3)

92.7 (84.0–100.0)

0.032*

Clinical outcomes

 Death (%)

28 (5.7)

18 (4.5)

0.527

 Death-censored graft loss (%)

42 (8.5)

53 (13.3)

0.022*

 Chronic allograft nephropathy

10 (2.0)

24 (6.0)

0.002*

 Chronic rejection

18 (3.7)

12 (3.0)

0.596

 Vascular complication

4 (0.8)

4 (1.0)

0.763

 Recurrent nephritis

2 (0.4)

4 (1.0)

0.278

 Infection

2 (0.4)

1 (0.3)

0.691

 Others

4 (0.8)

7 (1.8)

0.204

 Unknown

2 (0.4)

1 (0.3)

0.691

 Follow-up period (months)

146 (100–189)

116 (86–147)

< 0.001*

  1. Data for continuous variables are presented as median (interquartile range)
  2. DSA Donor-specific HLA antibody, eGFR Estimated glomerular filtration rate, HPT Hyperparathyroidism, MBP Mean blood pressure, NC-HPT Normocalcemic hyperparathyroidism, PTH Parathyroid hormone, KTx Kidney transplantation
  3. *P-value < 0.05
  4. The dialysis vintage was defined as 0 when preemptive KTx was performed