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Fig. 5 | BMC Nephrology

Fig. 5

From: Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1

Fig. 5

Modulation of CaV3.1 SKO, CaV3.2 SKO and MES13 cell proliferation by TTCC blockers. Cell proliferation of the CaV3.1, CaV3.2 knockout cells after treatment with TTCC blockers: mibefradil (a, b) and TH1177 (c, d) were compared to wild type control cells (MES13). Cell number was calculated by using the MTS assay in time points at 48 and 72 h. The data are represented as mean ± SD. Letters ‘abc’, ‘lmn’ and ‘xyz’ are used to denote the significance between drug concentration in control, CaV3.1 and CaV3.2 respectively. The same letter above the graphs indicates no change between the groups. Different letters above the graph indicate the significant difference between the means. The data are represented as mean ± SD, n = 4, **P < 0.01, ***P < 0.001 are for the comparison between KO to its respective control at each concentration. Two-Way ANOVA with Turkey post hoc correction

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