Table 8 Univariate and multivariate logistic regression analysis of factors associated with treatment outcome among patients with lupus nephritis on follow up at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia from Sep, 2016 to Oct, 2020 (n = 114)
Outcome variables | Treatment outcome | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
Good prognosis, n (%) | Poor prognosis, n (%) | COR(95%CI) | P-value | AOR(95% CI) | P-value | |
Gender | ||||||
Male | 14 (12.3) | 1 (0.9) | 0.236(0.029–1.892) | 0.17 | 0.07(0.003–1.537) | 0.091 |
Female | 76 (66.7) | 23 (20.2) | 1.000 | 1.000 | ||
Hypertension at onset | ||||||
Yes | 38(33.3) | 15(13.2%) | 0.438(0.174–1.107) | 0.08 | 0.58(0.155–2.196) | 0.425 |
No | 52(45.6) | 9(7.9) | 1.000 | 1.000 | ||
AKI at onset | ||||||
Yes | 30(26.3) | 18(15.8) | 6.00(2.158–16.683) | 0.001 | 4.83(1.207–19.286) | 0.026* |
No | 60(52.6) | 6(5.3) | 1.000 | 1.000 | ||
Baseline SCr. (mg/dl) | ||||||
> 1.5 mg/dl | 44(38.6) | 18(15.8) | 0.319(0.116–0.877) | 0.027 | 0.73(0.195–2.760) | 0.647 |
< 1.5 mg/dl | 46(40.4) | 6(5.3) | 1.000 | 1.000 | ||
Baseline urine proteins (g/24 h) | ||||||
> 3.5 g | 58(50.9) | 20(17.5) | 3.036(0.956–9.635) | 0.06 | 1.15(0.258–5.171) | 0.851 |
< 3.5 g | 32(28.1) | 4(3.5) | 1.000 | 1.000 | ||
Six month SCr value | ||||||
> 1.5 mg/dl | 12(10.5) | 16(14.0) | 0.077(0.027–0.218) | 0.000 | 0.12(0.030–0.475) | 0.003* |
< 1.5 mg/dl | 78(68.4) | 8(7.0) | 1.000 | 1.000 | ||
Response at six month | ||||||
CR | 23(20.2) | 1(0.9) | 0.127(0.016–0.991) | 0.049 | 0.05(0.003–0.891) | 0.041* |
No CR | 67(58.8) | 23(20.2) | 1.000 | 1.000 | ||
Hospitalization events | ||||||
Yes | 29(25.4) | 15(13.2) | 3.506(1.373–8.950) | 0.009 | 0.32(0.054–1.846) | 0.200 |
No | 61(53.5) | 9(7.9) | 1.000 | 1.000 | ||
Presence of flare | ||||||
Yes | 8(7.0) | 12(10.5) | 0.098(0.033–0.287) | 0.000 | 0.04(0.005–0.374) | 0.004* |
No | 82(71.9) | 12(10.5) | 1.000 | 1.000 | ||