Fig. 1
From: COL4A4 variant recently identified: lessons learned in variant interpretation—a case report
Kidney biopsy findings in patients 1 (A, B) and 2 (C, D). (A) In patient 1, light microscopy revealed marked non-specific chronic changes, and (B) on electron microscopy, there was significant effacement of podocyte foot processes, with attenuation and wrinkling of the basement membranes; numerous lamellar “zebra bodies” were noted in podocyte cytoplasm. (C) In patient 2, light microscopy revealed unremarkable parenchyma, while (D) electron microscopy was significant for markedly attenuated glomerular basement membranes